| Literature DB >> 8386975 |
W Mayo1, F Dellu, P Robel, J Cherkaoui, M Le Moal, E E Baulieu, H Simon.
Abstract
The neurosteroids, pregnenolone sulfate (PREG-S) and tetrahydroprogesterone (TH-PROG), act on the GABAA receptor with antagonist or agonist-like properties, respectively. In this study the effect of the infusion of PREG-S and TH-PROG into the nucleus basalis magnocellularis (NBM) of the rat was examined in a two-trial memory task. The results show that PREG-S (5 ng in 0.5 microliter) enhances memory performance when injected after an acquisition trial; conversely TH-PROG (2 ng in 0.5 microliter) disrupts performance when injected before an acquisition trial. A role for neurosteroids in memory processes subserved by the nucleus basalis magnocellularis is of interest in view of the implication of this structure and these substances in neurodegenerative processes.Entities:
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Year: 1993 PMID： 8386975 DOI： 10.1016/0006-8993(93)91524-v
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252