Literature DB >> 8386828

Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5.

D A Clements1, J K Wang, C A Dionne, M Goldfarb.   

Abstract

We have purified biologically active recombinant human fibroblast growth factor 5 (FGF-5) from Escherichia coli. In the presence of heparin, recombinant FGF-5 is as active as native growth factor, demonstrating that glycosylation does not significantly potentiate FGF-5 activity. FGF-5 can bind and induce autophosphorylation of human FGF receptors (FGFR) 1 and 2. Competition binding studies show that the KD for FGF-5-FGFR-1 and FGF-5-FGFR-2 interactions are both between 0.5 and 1.5 x 10(-9) M.

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Year:  1993        PMID： 8386828

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  12 in total

1.  Expression of scleraxis and tenascin C in equine adipose and umbilical cord blood derived stem cells is dependent upon substrata and FGF supplementation.

Authors:  Sarah A Reed; Sally E Johnson
Journal:  Cytotechnology       Date:  2013-01-09       Impact factor: 2.058

2.  FGF5 is a crucial regulator of hair length in humans.

Authors:  Claire A Higgins; Lynn Petukhova; Sivan Harel; Yuan Y Ho; Esther Drill; Lawrence Shapiro; Muhammad Wajid; Angela M Christiano
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-02       Impact factor: 11.205

3.  Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic cats.

Authors:  James S Kehler; Victor A David; Alejandro A Schäffer; Kristina Bajema; Eduardo Eizirik; David K Ryugo; Steven S Hannah; Stephen J O'Brien; Marilyn Menotti-Raymond
Journal:  J Hered       Date:  2007-09-01       Impact factor: 2.645

Review 4.  Regulation of prostate growth by fibroblast growth factors.

Authors:  M T Story
Journal:  World J Urol       Date:  1995       Impact factor: 4.226

5.  FGF-16 is released from neonatal cardiac myocytes and alters growth-related signaling: a possible role in postnatal development.

Authors:  Shun Yan Lu; David P Sontag; Karen A Detillieux; Peter A Cattini
Journal:  Am J Physiol Cell Physiol       Date:  2008-03-12       Impact factor: 4.249

6.  Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities.

Authors:  Omar A Ibrahimi; Fuming Zhang; Anna V Eliseenkova; Nobuyuki Itoh; Robert J Linhardt; Moosa Mohammadi
Journal:  Hum Mol Genet       Date:  2004-07-28       Impact factor: 6.150

7.  Fibroblast growth factor receptors have different signaling and mitogenic potentials.

Authors:  J K Wang; G Gao; M Goldfarb
Journal:  Mol Cell Biol       Date:  1994-01       Impact factor: 4.272

Review 8.  Transfected MCF-7 cells as a model for breast-cancer progression.

Authors:  F G Kern; S W McLeskey; L Zhang; J Kurebayashi; Y Liu; I Y Ding; S Kharbanda; D Chen; D Miller; K Cullen
Journal:  Breast Cancer Res Treat       Date:  1994       Impact factor: 4.872

9.  Heparin can activate a receptor tyrosine kinase.

Authors:  G Gao; M Goldfarb
Journal:  EMBO J       Date:  1995-05-15       Impact factor: 11.598

Review 10.  Directional protein secretion by the retinal pigment epithelium: roles in retinal health and the development of age-related macular degeneration.

Authors:  Paul Kay; Yit C Yang; Luminita Paraoan
Journal:  J Cell Mol Med       Date:  2013-05-11       Impact factor: 5.310
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