Literature DB >> 8386814

Alterations of selected enzymes of phospholipid metabolism in Alzheimer's disease brain tissue as compared to non-Alzheimer's demented controls.

J N Kanfer, J W Pettegrew, J Moossy, D G McCartney.   

Abstract

Previous studies have demonstrated elevated brain levels of phosphomonoesters in early stages of Alzheimer's disease and elevations of phosphodiesters later in the disease. In addition, preliminary quantitative analyses of the phospholipids of Alzheimer's brain reveals either decreases in some phospholipids or elevations followed by decreases in others. This study quantitated the activities of selected enzymes involved in phospholipid and choline metabolism and demonstrated elevated glycerol-3-phosphorylcholine phosphodiesterase and decreased choline kinase activities in Alzheimer's disease brain. The former could provide an enzymatic mechanism for the increased phosphorylcholine found in Alzheimer's disease brain.

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Year:  1993        PMID： 8386814     DOI： 10.1007/bf00969091

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  20 in total

1.  A rapid radiochemical method for the determination of choline acetyltransferase.

Authors:  F Fonnum
Journal:  J Neurochem       Date:  1975-02       Impact factor: 5.372

2.  A rat brain cytosolic N-methyltransferase(s) activity converting phosphorylethanolamine into phosphorylcholine.

Authors:  C Andriamampandry; R Massarelli; L Freysz; J N Kanfer
Journal:  Biochem Biophys Res Commun       Date:  1990-09-14       Impact factor: 3.575

3.  Bilateral symmetry of morphologic lesions in Alzheimer's disease.

Authors:  J Moossy; G S Zubenko; A J Martinez; G R Rao
Journal:  Arch Neurol       Date:  1988-03

4.  Developmental and regional quantitation of glycerophosphorylcholine phosphodiesterase activities in rat brain.

Authors:  J N Kanfer; D G McCartney
Journal:  Neurochem Res       Date:  1988-09       Impact factor: 3.996

5.  Reduced phospholipase D activity in brain tissue samples from Alzheimer's disease patients.

Authors:  J N Kanfer; H Hattori; D Orihel
Journal:  Ann Neurol       Date:  1986-08       Impact factor: 10.422

6.  Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer's disease but not of Down's syndrome patients.

Authors:  J K Blusztajn; I Lopez Gonzalez-Coviella; M Logue; J H Growdon; R J Wurtman
Journal:  Brain Res       Date:  1990-12-17       Impact factor: 3.252

7.  In vitro 31P NMR spectroscopy detects altered phospholipid metabolism in Alzheimer's disease.

Authors:  O Miatto; R G Gonzalez; F Buonanno; J H Growdon
Journal:  Can J Neurol Sci       Date:  1986-11       Impact factor: 2.104

8.  Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia.

Authors:  C Q Mountjoy; M N Rossor; L L Iversen; M Roth
Journal:  Brain       Date:  1984-06       Impact factor: 13.501

9.  Correlation of phosphorus-31 magnetic resonance spectroscopy and morphologic findings in Alzheimer's disease.

Authors:  J W Pettegrew; K Panchalingam; J Moossy; J Martinez; G Rao; F Boller
Journal:  Arch Neurol       Date:  1988-10

10.  31P nuclear magnetic resonance studies of phosphoglyceride metabolism in developing and degenerating brain: preliminary observations.

Authors:  J W Pettegrew; S J Kopp; N J Minshew; T Glonek; J M Feliksik; J P Tow; M M Cohen
Journal:  J Neuropathol Exp Neurol       Date:  1987-07       Impact factor: 3.685
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  6 in total

1.  Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.

Authors:  Li Zhu; Minghao Zhong; Gregory A Elder; Mary Sano; David M Holtzman; Sam Gandy; Christopher Cardozo; Vahram Haroutunian; Nikolaos K Robakis; Dongming Cai
Journal:  Proc Natl Acad Sci U S A       Date:  2015-09-08       Impact factor: 11.205

Review 2.  Phospholipase D in brain function and Alzheimer's disease.

Authors:  Tiago Gil Oliveira; Gilbert Di Paolo
Journal:  Biochim Biophys Acta       Date:  2010-04-23

3.  Brain membrane phospholipid alterations in Alzheimer's disease.

Authors:  J W Pettegrew; K Panchalingam; R L Hamilton; R J McClure
Journal:  Neurochem Res       Date:  2001-07       Impact factor: 3.996

4.  Multiple forms of the enzyme glycerophosphodiesterase are present in human brain.

Authors:  B M Ross; A L Sherwin; S J Kish
Journal:  Lipids       Date:  1995-12       Impact factor: 1.880

Review 5.  Nature Versus Nurture: Does Proteostasis Imbalance Underlie the Genetic, Environmental, and Age-Related Risk Factors for Alzheimer's Disease?

Authors:  Elise A Kikis
Journal:  Healthcare (Basel)       Date:  2017-08-22

6.  MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis.

Authors:  Jiqing Cao; Min Huang; Lei Guo; Li Zhu; Jianwei Hou; Larry Zhang; Adriana Pero; Sabrina Ng; Farida El Gaamouch; Gregory Elder; Mary Sano; Alison Goate; Julia Tcw; Vahram Haroutunian; Bin Zhang; Dongming Cai
Journal:  Mol Psychiatry       Date:  2020-07-06       Impact factor: 15.992
  6 in total

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