Literature DB >> 8386696

The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma.

J A Byrne1, P J Smith.   

Abstract

We have utilized the polymerase chain reaction (PCR) to amplify a transcribed Taq1 polymorphism in the ribonucleotide reductase M1 subunit (RRM1) gene at chromosome 11p15.5, to investigate whether this locus is subjected to imprinting in embryonal tumours. The polymorphism was amplified from cDNA from 6 Wilms' tumours, one hepatoblastoma and corresponding samples of adjacent kidney or liver from individuals who were constitutionally heterozygous for the polymorphism. Taq1 digestion of PCR products revealed that both alleles were transcribed in all samples where both were present at the genomic level, indicating that the RRM1 locus is not subjected to imprinting in Wilms' tumour or hepatoblastoma.

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Year:  1993        PMID： 8386696     DOI： 10.1007/bf00218271

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  14 in total

1.  Chromosome 11 uniparental isodisomy predisposing to embryonal neoplasms.

Authors:  P Grundy; P Telzerow; M C Paterson; D Haber; B Berman; F Li; J Garber
Journal:  Lancet       Date:  1991-10-26       Impact factor: 79.321

2.  New TaqI polymorphism in the RRM1 gene.

Authors:  J Byrne; N Parker; R Fox; P Smith
Journal:  Nucleic Acids Res       Date:  1991-10-25       Impact factor: 16.971

Review 3.  Paternal origin of 11p15 duplications in the Beckwith-Wiedemann syndrome. A new case and review of the literature.

Authors:  K W Brown; A Gardner; J C Williams; M G Mott; A McDermott; N J Maitland
Journal:  Cancer Genet Cytogenet       Date:  1992-01

4.  Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes.

Authors:  N J Parker; C G Begley; R M Fox
Journal:  Nucleic Acids Res       Date:  1991-07-11       Impact factor: 16.971

5.  Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping.

Authors:  H J Scrable; D P Witte; B C Lampkin; W K Cavenee
Journal:  Nature       Date:  1987 Oct 15-21       Impact factor: 49.962

6.  Uniparental paternal disomy in a genetic cancer-predisposing syndrome.

Authors:  I Henry; C Bonaiti-Pellié; V Chehensse; C Beldjord; C Schwartz; G Utermann; C Junien
Journal:  Nature       Date:  1991-06-20       Impact factor: 49.962

Review 7.  Genome imprinting and carcinogenesis.

Authors:  C Sapienza
Journal:  Biochim Biophys Acta       Date:  1991-04-16

8.  Preferential loss of maternal alleles in sporadic Wilms' tumour.

Authors:  N Pal; R B Wadey; B Buckle; E Yeomans; J Pritchard; J K Cowell
Journal:  Oncogene       Date:  1990-11       Impact factor: 9.867

9.  Monoallelic expression of the human H19 gene.

Authors:  Y Zhang; B Tycko
Journal:  Nat Genet       Date:  1992-04       Impact factor: 38.330

10.  Equivalent expression of paternally and maternally inherited WT1 alleles in normal fetal tissue and Wilms' tumours.

Authors:  M H Little; R Dunn; J A Byrne; A Seawright; P J Smith; K Pritchard-Jones; V van Heyningen; N D Hastie
Journal:  Oncogene       Date:  1992-04       Impact factor: 9.867
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  4 in total

Review 1.  Genomic imprinting: mechanism and role in human pathology.

Authors:  B Tycko
Journal:  Am J Pathol       Date:  1994-03       Impact factor: 4.307

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Authors:  L M Sargent; X Zhou; C L Keck; N D Sanderson; D B Zimonjic; N C Popescu; S S Thorgeirsson
Journal:  Am J Pathol       Date:  1999-04       Impact factor: 4.307

Review 3.  Therapeutic Value of Single Nucleotide Polymorphisms on the Efficacy of New Therapies in Patients with Multiple Sclerosis.

Authors:  María José Zarzuelo Romero; Cristina Pérez Ramírez; María Isabel Carrasco Campos; Almudena Sánchez Martín; Miguel Ángel Calleja Hernández; María Carmen Ramírez Tortosa; Alberto Jiménez Morales
Journal:  J Pers Med       Date:  2021-04-23

4.  Discovering hidden connections among diseases, genes and drugs based on microarray expression profiles with negative-term filtering.

Authors:  Jain-Shing Wu; E-Fong Kao; Chung-Nan Lee
Journal:  PLoS One       Date:  2014-06-10       Impact factor: 3.240
  4 in total

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