Literature DB >> 8385773

Phosphatase inhibition by calyculin A increases i(f) in canine Purkinje fibers and myocytes.

H Yu1, F Chang, I S Cohen.   

Abstract

The actions of the phosphatase inhibitor calyculin A on the pacemaker current i(f) were studied in canine Purkinje fibers and myocytes. Calyculin A increased i(f) in response to hyperpolarizations toward the middle of the i(f) activation curve. A three pulse protocol indicated this increase was due to a positive shift of i(f) activation on the voltage axis. Taken together with our previous results (that kinase inhibition with H7 shifts i(f) activation in the negative direction on the voltage axis (2)), these results suggest that phosphorylation is an important regulator of the voltage dependence of i(f) activation.

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Year:  1993        PMID： 8385773     DOI： 10.1007/bf00374010

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  8 in total

1.  Regulation of Ca(2+)-activated K+ channels by protein kinase A and phosphatase inhibitors.

Authors:  A Carl; J L Kenyon; D Uemura; N Fusetani; K M Sanders
Journal:  Am J Physiol       Date:  1991-08

2.  Effects of protein kinase inhibitors on canine Purkinje fibre pacemaker depolarization and the pacemaker current i(f).

Authors:  F Chang; I S Cohen; D DiFrancesco; M R Rosen; C Tromba
Journal:  J Physiol       Date:  1991       Impact factor: 5.182

Review 3.  The cardiac hyperpolarizing-activated current, if. Origins and developments.

Authors:  D DiFrancesco
Journal:  Prog Biophys Mol Biol       Date:  1985       Impact factor: 3.667

4.  Calcium-independent activation of contractile apparatus in smooth muscle by calyculin-A.

Authors:  H Ishihara; H Ozaki; K Sato; M Hori; H Karaki; S Watabe; Y Kato; N Fusetani; K Hashimoto; D Uemura
Journal:  J Pharmacol Exp Ther       Date:  1989-07       Impact factor: 4.030

5.  Properties of an electrogenic sodium-potassium pump in isolated canine Purkinje myocytes.

Authors:  I S Cohen; N B Datyner; G A Gintant; N K Mulrine; P Pennefather
Journal:  J Physiol       Date:  1987-02       Impact factor: 5.182

6.  Modulation by intracellular Ca2+ of the hyperpolarization-activated inward current in rabbit single sino-atrial node cells.

Authors:  N Hagiwara; H Irisawa
Journal:  J Physiol       Date:  1989-02       Impact factor: 5.182

7.  Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.

Authors:  H Ishihara; B L Martin; D L Brautigan; H Karaki; H Ozaki; Y Kato; N Fusetani; S Watabe; K Hashimoto; D Uemura
Journal:  Biochem Biophys Res Commun       Date:  1989-03-31       Impact factor: 3.575

8.  Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.

Authors:  D DiFrancesco; P Tortora
Journal:  Nature       Date:  1991-05-09       Impact factor: 49.962
  8 in total
  16 in total

Review 1.  Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels.

Authors:  David Weisbrod; Shiraz Haron Khun; Hanna Bueno; Asher Peretz; Bernard Attali
Journal:  Acta Pharmacol Sin       Date:  2016-01       Impact factor: 6.150

Review 2.  Regulation of recombinant and native hyperpolarization-activated cation channels.

Authors:  Samuel G A Frère; Mira Kuisle; Anita Lüthi
Journal:  Mol Neurobiol       Date:  2004-12       Impact factor: 5.590

Review 3.  Creating a cardiac pacemaker by gene therapy.

Authors:  Traian M Anghel; Steven M Pogwizd
Journal:  Med Biol Eng Comput       Date:  2006-12-01       Impact factor: 2.602

4.  Constitutively active Src tyrosine kinase changes gating of HCN4 channels through direct binding to the channel proteins.

Authors:  Suzanne S Arinsburg; Ira S Cohen; Han-Gang Yu
Journal:  J Cardiovasc Pharmacol       Date:  2006-04       Impact factor: 3.105

5.  Novel mechanism for suppression of hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by receptor-like tyrosine phosphatase-alpha.

Authors:  Jianying Huang; Aijie Huang; Qi Zhang; Yen-Chang Lin; Han-Gang Yu
Journal:  J Biol Chem       Date:  2008-09-03       Impact factor: 5.157

6.  Muscarinic-activated potassium current mediates the negative chronotropic effect of pilocarpine on the rabbit sinoatrial node.

Authors:  Martín Rodríguez-Martínez; Iván A Aréchiga-Figueroa; Eloy G Moreno-Galindo; Ricardo A Navarro-Polanco; José A Sánchez-Chapula
Journal:  Pflugers Arch       Date:  2011-04-13       Impact factor: 3.657

7.  Pacemaker current i(f) in adult canine cardiac ventricular myocytes.

Authors:  H Yu; F Chang; I S Cohen
Journal:  J Physiol       Date:  1995-06-01       Impact factor: 5.182

8.  Age-dependent differences in the inhibition of HCN2 current in rat ventricular myocytes by the tyrosine kinase inhibitor erbstatin.

Authors:  Yelena Kryukova; Vitalyi O Rybin; Jihong Qu; Susan F Steinberg; Richard B Robinson
Journal:  Pflugers Arch       Date:  2008-08-12       Impact factor: 3.657

9.  Differential modulation of pharmacologically distinct components of Ca2+ currents by protein kinase C activators and phosphatase inhibitors in nerve-growth-factor-differentiated rat pheochromocytoma (PC12) cells.

Authors:  A Bouron; B F Reber
Journal:  Pflugers Arch       Date:  1994-07       Impact factor: 3.657

10.  I(f) current mediates beta-adrenergic enhancement of heart rate but not contractility in vivo.

Authors:  B D Guth; T Dietze
Journal:  Basic Res Cardiol       Date:  1995 May-Jun       Impact factor: 17.165
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