| Literature DB >> 8385761 |
K Takahashi1, H Kameda, M Kataoka, K Sanjou, N Harata, N Akaike.
Abstract
The ammonium ion (NH4+) evoked no response itself but facilitated the GABA-induced Cl- current (ICl) in dissociated rat cortical neurons. The GABA concentration-response curve shifted parallely to the left without changing the maximum response. Reversal potential of GABA response did not change in the presence of NH4+ at the concentration range between 0.1 and 1 mM. Ro 15-1788, a selective benzodiazepine receptor antagonist, did not affect the facilitatory action of NH4+ on GABAA receptor. The results suggest that NH4+ modifies the affinity of GABAA receptor for GABA, without the involvement of benzodiazepine receptors.Entities:
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Year: 1993 PMID： 8385761 DOI： 10.1016/0304-3940(93)90043-k
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046