Mutations in the yeast fructose 1,6-biphosphatase structural gene affect expression of a fructose 1,6-biphosphatase-endoglucanase A hybrid protein.

Mutations in the yeast fructose 1,6 biphosphatase structural gene severely reduced expression of a fructose 1,6 biphosphatase-endoglucanase A hybrid protein introduced into yeast on multicopy or centromeric vectors. Upon glucose limitation the mutant yeasts were incapable of de-repressing endoglucanase A synthesis.