| Literature DB >> 8385083 |
Y Iwahara1, T Sawada, H Taguchi, H Hoshino, M Umemoto, H Take, S Foung, I Miyoshi.
Abstract
Breast feeding is the major route of mother-to-child transmission of human T-cell leukemia virus type I (HTLV-I). Our experiments with rabbits have shown that passive immunization is capable of blocking cell-to-cell infection of HTLV-I by blood transfusion or breast feeding. In this study, sera were collected serially from 3 infants born to seropositive mothers and were tested for the presence of neutralizing antibody to vesicular stomatitis virus (HTLV-I) pseudotype as well as antibodies to viral structural proteins. There was a good correlation between neutralizing and viral antibody titers, both of which were detectable until 3-6 months after birth. Whether maternally transmitted neutralizing antibody is protective against perinatal infection of HTLV-I remains to be studied.Entities:
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Year: 1993 PMID： 8385083 PMCID： PMC5919125 DOI： 10.1111/j.1349-7006.1993.tb02842.x
Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050