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Literature DB >> 8384746

Identification of a trans-acting activity from liver that stimulates hepatitis A virus translation in vitro.

Abstract

Hepatitis A virus (HAV), a picornavirus, is the causative agent of infectious hepatitis, generally a self-limiting disease of the liver. Recently, sequences within the 5' noncoding region that affect the translation of the viral genome have been identified using in vitro systems. In this report we demonstrate that extracts prepared from mouse liver cytoplasm specifically stimulate HAV RNA translation in a rabbit reticulocyte lysate in vitro. This activity appears to act specifically on HAV sequences and is not found in other mouse tissue and several cell lines of tissue culture origin.

Entities: Disease Species

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Year: 1993 PMID： 8384746 DOI： 10.1006/viro.1993.1225

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616

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Cited

21 in total

1. Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis by alternative translational initiation at multiple AUG start sites.

Authors: W Xiong; C C Hsieh; A J Kurtz; J P Rabek; J Papaconstantinou
Journal: Nucleic Acids Res Date: 2001-07-15 Impact factor: 16.971

2. Functional involvement of polypyrimidine tract-binding protein in translation initiation complexes with the internal ribosome entry site of foot-and-mouth disease virus.

Authors: M Niepmann; A Petersen; K Meyer; E Beck
Journal: J Virol Date: 1997-11 Impact factor: 5.103

3. Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins.

Authors: L O Roberts; R A Seamons; G J Belsham
Journal: RNA Date: 1998-05 Impact factor: 4.942

Review 4. RNA-protein interactions in regulation of picornavirus RNA translation.

Authors: G J Belsham; N Sonenberg
Journal: Microbiol Rev Date: 1996-09

5. Interaction of poly(rC) binding protein 2 with the 5' noncoding region of hepatitis A virus RNA and its effects on translation.

Authors: J Graff; J Cha; L B Blyn; E Ehrenfeld
Journal: J Virol Date: 1998-12 Impact factor: 5.103

10. Low efficiency of the 5' nontranslated region of hepatitis A virus RNA in directing cap-independent translation in permissive monkey kidney cells.

Authors: L E Whetter; S P Day; O Elroy-Stein; E A Brown; S M Lemon
Journal: J Virol Date: 1994-08 Impact factor: 5.103

Identification of a trans-acting activity from liver that stimulates hepatitis A virus translation in vitro.

1. Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis by alternative translational initiation at multiple AUG start sites.

2. Functional involvement of polypyrimidine tract-binding protein in translation initiation complexes with the internal ribosome entry site of foot-and-mouth disease virus.

3. Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins.

Review 4. RNA-protein interactions in regulation of picornavirus RNA translation.

5. Interaction of poly(rC) binding protein 2 with the 5' noncoding region of hepatitis A virus RNA and its effects on translation.

6. Coding sequences enhance internal initiation of translation by hepatitis A virus RNA in vitro.

7. A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs.

8. Evolution of a common structural core in the internal ribosome entry sites of picornavirus.

Review 9. Internal initiation of translation of picornavirus RNAs.

10. Low efficiency of the 5' nontranslated region of hepatitis A virus RNA in directing cap-independent translation in permissive monkey kidney cells.