Literature DB >> 8384744

The pseudorabies virus host-shutoff homolog gene: nucleotide sequence and comparison with alphaherpesvirus protein counterparts.

H Berthomme1, B Jacquemont, A Epstein.   

Abstract

The virion host shutoff function (VHS) of many herpesviruses is required for inhibition of cellular gene expression in infected cells. This function corresponds to the UL41 open reading frame of herpes simplex virus type 1 (HSV-1) and homolog sequences have been found in other alphaherpesvirus, like HSV-2, Varicella-Zoster virus (VZV) and equine herpesvirus type 1 (EHV-1). In this work, we have cloned and sequenced a pseudorabies virus (PRV) gene which is homologous to the VHS genes of the other alphaherpesvirus. Sequence comparison between all deduced amino acid sequences indicates the presence of several conserved domains, separated by regions containing gaps or low conserved sequences.

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Year:  1993        PMID： 8384744     DOI： 10.1006/viro.1993.1221

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  32 in total

1.  mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease.

Authors:  David N Everly; Pinghui Feng; I Saira Mian; G Sullivan Read
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

2.  The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA.

Authors:  A J Doherty; L C Serpell; C P Ponting
Journal:  Nucleic Acids Res       Date:  1996-07-01       Impact factor: 16.971

3.  Role of the VP16-binding domain of vhs in viral growth, host shutoff activity, and pathogenesis.

Authors:  Stephanie S Strand; David A Leib
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

4.  Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras.

Authors:  D N Everly; G S Read
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

5.  Mode of virus rescue determines the acquisition of VHS mutations in VP22-negative herpes simplex virus 1.

Authors:  Katja Ebert; Daniel P Depledge; Judith Breuer; Laura Harman; Gillian Elliott
Journal:  J Virol       Date:  2013-07-17       Impact factor: 5.103

6.  Identification and characterization of a small modular domain in the herpes simplex virus host shutoff protein sufficient for interaction with VP16.

Authors:  J Schmelter; J Knez; J R Smiley; J P Capone
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

7.  Analysis of conserved domains of UL41 of herpes simplex virus type 1 in virion host shutoff and pathogenesis.

Authors:  L I Strelow; D A Leib
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

8.  Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis.

Authors:  L I Strelow; D A Leib
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

9.  Cloning, sequencing, and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: evidence for specificity of interaction.

Authors:  H Berthomme; S J Monahan; D S Parris; B Jacquemont; A L Epstein
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

10.  Activation of CNS circuits producing a neurogenic cystitis: evidence for centrally induced peripheral inflammation.

Authors:  L Jasmin; G Janni; H J Manz; S D Rabkin
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167
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