| Literature DB >> 8382624 |
S M Jhiang1, L Fithian, P Smanik, J McGill, Q Tong, E L Mazzaferri.
Abstract
A cDNA clone encoding a taurine transporter, designated HTAU, has been isolated from human thyroid. It contains an open reading frame encoding a protein of 619 amino acids with a calculated molecular weight of 69,675 Da. The predicted amino acid sequence of HTAU is highly homologous to those of dog kidney and rat brain. The HTAU mRNA was detectable in various human tissues examined. Transient expression of HTAU in COS-7 cells conferred a higher taurine uptake. The taurine uptake in FRTL-5 cells appears to be regulated by thyrotropin through cAMP. Finally, a higher taurine uptake may be associated with a higher proliferation rate in some cultured cell lines.Entities:
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Year: 1993 PMID： 8382624 DOI： 10.1016/0014-5793(93)80008-i
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124