Literature DB >> 8382486

Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system.

H Okazaki1, N Ishizaka, T Sakurai, K Kurokawa, K Goto, M Kumada, Y Takuwa.   

Abstract

A novel cDNA clone encoding a putative G protein-coupled receptor has been isolated from a rat aortic smooth muscle cDNA library. Sequence analysis of this clone reveals the structural features characteristic of this superfamily, with a high degree of sequence similarity to the Edg-1 receptor previously reported to be expressed in vascular endothelial cells. This novel receptor mRNA is expressed predominantly in the lung and heart. Although the ligand for this receptor has yet to be identified, the results suggest the existence of a new receptor subfamily in the cardiovascular system thus far unrecognized.

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Year:  1993        PMID： 8382486     DOI： 10.1006/bbrc.1993.1163

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  29 in total

1.  Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3.

Authors:  H Okamoto; N Takuwa; T Yokomizo; N Sugimoto; S Sakurada; H Shigematsu; Y Takuwa
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

Review 2.  Insights into the pharmacological relevance of lysophospholipid receptors.

Authors:  Tetsuji Mutoh; Richard Rivera; Jerold Chun
Journal:  Br J Pharmacol       Date:  2012-02       Impact factor: 8.739

Review 3.  Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells.

Authors:  Nigel J Pyne; Catherine M Waters; Jaclyn S Long; Noreen A Moughal; Gabor Tigyi; Susan Pyne
Journal:  Adv Enzyme Regul       Date:  2007-03-06

Review 4.  Regulation of vascular physiology and pathology by the S1P2 receptor subtype.

Authors:  Athanasia Skoura; Timothy Hla
Journal:  Cardiovasc Res       Date:  2009-03-15       Impact factor: 10.787

5.  Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde.

Authors:  Noriko Takuwa; Wa Du; Erika Kaneko; Yasuo Okamoto; Kazuaki Yoshioka; Yoh Takuwa
Journal:  Am J Cancer Res       Date:  2011-02-16       Impact factor: 6.166

6.  Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats.

Authors:  A Bischoff; D Meyer Zu Heringdorf; K H Jakobs; M C Michel
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

7.  Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1.

Authors:  G C Zondag; F R Postma; I V Etten; I Verlaan; W H Moolenaar
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

8.  Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma.

Authors:  Mei-Hong Li; Rolf Swenson; Miriam Harel; Sampa Jana; Erik Stolarzewicz; Timothy Hla; Linda H Shapiro; Fernando Ferrer
Journal:  J Pharmacol Exp Ther       Date:  2015-06-23       Impact factor: 4.030

9.  Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.

Authors:  S Salomone; E M Potts; S Tyndall; P C Ip; J Chun; V Brinkmann; C Waeber
Journal:  Br J Pharmacol       Date:  2007-11-19       Impact factor: 8.739

Review 10.  Sphingosine-1-phosphate receptor 2.

Authors:  Mohamad Adada; Daniel Canals; Yusuf A Hannun; Lina M Obeid
Journal:  FEBS J       Date:  2013-08-19       Impact factor: 5.542
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