Literature DB >> 8381636

Candidicidal activity of the human recombinant myeloperoxidase system.

C Tournay1, P Majerus, M Pourtois, N Moguilevsky, A Bollen.   

Abstract

The effect of the human recombinant myeloperoxidase (recMPO) system on the viability of Candida albicans blastospores was determined. Cells were incubated in the presence of the enzyme, H2O2, and various substrates. In optimal conditions, 100% mortality was reached with only 41 mU of recMPO per ml, confirming its powerful candidicidal activity.

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Year:  1993        PMID: 8381636      PMCID: PMC187623          DOI: 10.1128/AAC.37.1.142

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  Antimicrobial polypeptides of human neutrophils.

Authors:  R I Lehrer; T Ganz
Journal:  Blood       Date:  1990-12-01       Impact factor: 22.113

Review 2.  Myeloperoxidase deficiency.

Authors:  W M Nauseef
Journal:  Hematol Pathol       Date:  1990

Review 3.  Chronic granulomatous disease.

Authors:  J T Curnutte; B M Babior
Journal:  Adv Hum Genet       Date:  1987

4.  Leukocyte myeloperoxidase deficiency and diabetes mellitus associated with Candida albicans liver abscess.

Authors:  P Cech; H Stalder; J J Widmann; A Rohner; P A Miescher
Journal:  Am J Med       Date:  1979-01       Impact factor: 4.965

Review 5.  Opportunistic mycoses in the immunocompromised host: experience at a cancer center and review.

Authors:  E Anaissie
Journal:  Clin Infect Dis       Date:  1992-03       Impact factor: 9.079

6.  The fungicidal mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperoxidase-independent candidacidal mechanisms.

Authors:  R I Lehrer
Journal:  J Clin Invest       Date:  1975-02       Impact factor: 14.808

7.  Damage to Candida albicans hyphae and pseudohyphae by the myeloperoxidase system and oxidative products of neutrophil metabolism in vitro.

Authors:  R D Diamond; R A Clark; C C Haudenschild
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808

8.  Phagolysosomal pH of human neutrophils.

Authors:  P Cech; R I Lehrer
Journal:  Blood       Date:  1984-01       Impact factor: 22.113

9.  Long-lived oxidants generated by human neutrophils: characterization and bioactivity.

Authors:  S J Weiss; M B Lampert; S T Test
Journal:  Science       Date:  1983-11-11       Impact factor: 47.728

10.  Myeloperoxidase-halide-hydrogen peroxide antibacterial system.

Authors:  S J Klebanoff
Journal:  J Bacteriol       Date:  1968-06       Impact factor: 3.490

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