Literature DB >> 8381358

Cholera toxin but not pertussis toxin inhibits angiotensin II-enhanced contractions in the rat portal vein.

J Zhang1, J C Van Meel, M Pfaffendorf, P A Van Zwieten.   

Abstract

Angiotensin II (Ang II)-enhanced phasic contractions in the rat portal vein were concentration dependently inhibited by cholera toxin (0.1-10 micrograms/ml) and dibutyryl cyclic AMP (0.1-1 mM), but not by pertussis toxin (1 micrograms/ml), which suggests that Gi is not involved in the Ang II signal transduction pathway. It also seems likely that the effect of cholera toxin is due to its ability to increase cyclic AMP production through Gs.

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Year:  1993        PMID： 8381358     DOI： 10.1016/0014-2999(93)90415-e

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

1.  G-protein involvement in muscarinic receptor-stimulation of inositol phosphates in longitudinal smooth muscle from the small intestine of the guinea-pig.

Authors:  S A Prestwich; T B Bolton
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

2.  Inhibitory effect of dithiothreitol on angiotensin II-induced contractions mediated by AT1-receptors in rat portal vein and rabbit aorta.

Authors:  J S Zhang; J C van Meel; M Pfaffendorf; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-05       Impact factor: 3.000

Review 3.  Association of Pertussis Toxin with Severe Pertussis Disease.

Authors:  Karen Scanlon; Ciaran Skerry; Nicholas Carbonetti
Journal:  Toxins (Basel)       Date:  2019-06-27       Impact factor: 4.546
  3 in total

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