Literature DB >> 8380773

Activation of phosphatidylinositol lipid-specific phospholipase C-beta 3 by G-protein beta gamma subunits.

A Carozzi1, M Camps, P Gierschik, P J Parker.   

Abstract

A novel member of the inositol lipid-specific phospholipase C family, PtdIns-PLC beta 3, is shown to be activated by beta gamma subunits of the heterotrimeric GTP-binding protein, transducin. The activation is a direct effect since it is observed with the purified proteins. Furthermore, the activation is blocked by the GDP-liganded alpha subunit of transducin, confirming that the effect is due to free beta gamma subunits. The implications with respect to receptor-PtdIns-PLC coupling are discussed.

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Year:  1993        PMID： 8380773     DOI： 10.1016/0014-5793(93)81190-b

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

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2.  G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: Lack of receptor selectivity of Galpha(16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein.

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3.  Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.

Authors:  D Wu; A Katz; M I Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

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Review 5.  The C2 domain calcium-binding motif: structural and functional diversity.

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6.  A segment of the C-terminal half of the G-protein beta 1 subunit specifies its interaction with the gamma 1 subunit.

Authors:  A Katz; M I Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-14       Impact factor: 11.205

7.  Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

Authors:  S Tsukada; M I Simon; O N Witte; A Katz
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8.  Inositol 1,4,5-trisphosphate formation and ryanodine-sensitive oscillations of cytosolic free Ca2+ concentrations in neuroblastoma x fibroblast hybrid NL308 cells expressing m2 and m4 muscarinic acetylcholine receptor subtypes.

Authors:  N Ishizaka; M Noda; Y Kimura; M Hashii; K Fukuda; M Katayama; D A Brown; H Higashida
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9.  Mu-opioids activate phospholipase C in SH-SY5Y human neuroblastoma cells via calcium-channel opening.

Authors:  D Smart; G Smith; D G Lambert
Journal:  Biochem J       Date:  1995-01-15       Impact factor: 3.857

10.  Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.

Authors:  A L Drayer; J Van der Kaay; G W Mayr; P J Van Haastert
Journal:  EMBO J       Date:  1994-04-01       Impact factor: 11.598
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