| Literature DB >> 8380771 |
E Acquas1, M Meloni, G Di Chiara.
Abstract
Naltrindole, a specific delta-opioid antagonist, infused by reverse dialysis in the nucleus accumbens of freely moving rats completely prevented the increase in extracellular dopamine concentrations elicited in the nucleus accumbens by ethanol (1.0 g/kg i.p.) as well as by the delta-opioid receptor agonist [D-Ala2]deltorphin II (50 microM), also perfused by reverse dialysis, but not by cocaine (15 mg/kg s.c.). The results provide in vivo evidence for a critical role of delta-opioid receptors in the dopamine-releasing properties of ethanol in vivo.Entities:
Mesh：
Substances：
Year: 1993 PMID： 8380771 DOI： 10.1016/0014-2999(93)90809-v
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432