Literature DB >> 8380559

Neurotensin stimulates cyclic AMP formation in CHO-rNTR-10 cells expressing the cloned rat neurotensin receptor.

M Yamada1, M Yamada1, M A Watson, E Richelson.   

Abstract

Recently, we reported that the rat neurotensin receptor expressed in transfected Chinese hamster ovary cells (CHO-rNTR-10) mediates the hydrolysis of polyphosphoinositides. In this study, we show that neurotensin stimulated cyclic AMP formation in CHO-rNTR-10 cells in a dose-dependent manner (EC50 = 34 nM). Neurotensin also stimulated cyclic AMP formation in membranal preparations under Ca(2+)-free conditions. These results suggest that this cyclic AMP formation occurs from direct coupling of the neurotensin receptor to a type of GTP binding protein, mediating synthesis of cyclic AMP, and not from an increase in intracellular Ca2+ concentration from polyphosphoinositide hydrolysis.

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Year:  1993        PMID： 8380559     DOI： 10.1016/0922-4106(93)90064-g

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Neurotensinergic augmentation of glutamate release at the perforant path-granule cell synapse in rat dentate gyrus: Roles of L-Type Ca²⁺ channels, calmodulin and myosin light-chain kinase.

Authors:  Haopeng Zhang; Hailong Dong; Saobo Lei
Journal:  Neuropharmacology       Date:  2015-04-02       Impact factor: 5.250

Review 2.  Neurotensin receptors: binding properties, transduction pathways, and structure.

Authors:  J P Vincent
Journal:  Cell Mol Neurobiol       Date:  1995-10       Impact factor: 5.046

3.  Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24.

Authors:  C Poinot-Chazel; M Portier; M Bouaboula; N Vita; F Pecceu; D Gully; J G Monroe; J P Maffrand; G Le Fur; P Casellas
Journal:  Biochem J       Date:  1996-11-15       Impact factor: 3.857

4.  Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation.

Authors:  N T Burford; S R Nahorski
Journal:  Biochem J       Date:  1996-05-01       Impact factor: 3.857

5.  Characterization of the effect of SR48692 on inositol monophosphate, cyclic GMP and cyclic AMP responses linked to neurotensin receptor activation in neuronal and non-neuronal cells.

Authors:  F Oury-Donat; O Thurneyssen; N Gonalons; P Forgez; D Gully; G Le Fur; P Soubrie
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

6.  Suppression of Gq Function Using Intra-Pipette Delivery of shRNA during Extracellular Recording in the Ventral Tegmental Area.

Authors:  Sudarat Nimitvilai; Devinder S Arora; Maureen A McElvain; Mark S Brodie
Journal:  Front Cell Neurosci       Date:  2013-02-12       Impact factor: 5.505
  6 in total

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