Literature DB >> 8380096

Marker rescue of a transformation-negative Epstein-Barr virus recombinant from an infected Burkitt lymphoma cell line: a method useful for analysis of genes essential for transformation.

A Marchini1, E Kieff, R Longnecker.   

Abstract

A Burkitt lymphoma cell line infected in vitro with a transformation-defective mutant recombinant Epstein-Barr virus (EBV) was used to attempt marker rescue of transformation competence by transfection with cloned wild-type DNA. EBV replication was induced in the transfected cells, and wild-type EBV DNA recombined via flanking homologous sequences adjacent to the deletion, resulting in a virus which transformed primary B lymphocytes in vitro. This strategy should be useful for molecular genetic analysis of the role of part or all of any gene in cell growth transformation.

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Year:  1993        PMID： 8380096      PMCID： PMC237404     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  15 in total

1.  Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation.

Authors:  J I Cohen; F Wang; J Mannick; E Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

2.  Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma.

Authors:  J Menezes; W Leibold; G Klein; G Clements
Journal:  Biomedicine       Date:  1975-07

3.  Epstein-Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein.

Authors:  S D Abbot; M Rowe; K Cadwallader; A Ricksten; J Gordon; F Wang; L Rymo; A B Rickinson
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

4.  Influence of the Epstein-Barr virus nuclear antigen EBNA 2 on the growth phenotype of virus-transformed B cells.

Authors:  A B Rickinson; L S Young; M Rowe
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

5.  Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells.

Authors:  K P Mann; D Staunton; D A Thorley-Lawson
Journal:  J Virol       Date:  1985-09       Impact factor: 5.103

6.  Transformation by Epstein-Barr virus requires DNA sequences in the region of BamHI fragments Y and H.

Authors:  J Skare; J Farley; J L Strominger; K O Fresen; M S Cho; H zur Hausen
Journal:  J Virol       Date:  1985-08       Impact factor: 5.103

7.  Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes.

Authors:  W Hammerschmidt; B Sugden
Journal:  Nature       Date:  1989-08-03       Impact factor: 49.962

8.  Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.

Authors:  F Wang; S F Tsang; M G Kurilla; J I Cohen; E Kieff
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

9.  Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection, and interference.

Authors:  G Miller; J Robinson; L Heston; M Lipman
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205

10.  Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells.

Authors:  M Rabson; L Heston; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205
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  9 in total

Review 1.  The genetic approach to the Epstein-Barr virus: from basic virology to gene therapy.

Authors:  H J Delecluse; W Hammerschmidt
Journal:  Mol Pathol       Date:  2000-10

2.  Epstein-Barr virus essential antigen EBNA3C attenuates H2AX expression.

Authors:  Hem C Jha; Mahadesh Prasad A J; Abhik Saha; Shuvomoy Banerjee; Jie Lu; Erle S Robertson
Journal:  J Virol       Date:  2014-01-15       Impact factor: 5.103

3.  Epstein-Barr virus vectors for gene delivery to B lymphocytes.

Authors:  E S Robertson; T Ooka; E D Kieff
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

4.  Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation.

Authors:  K M Izumi; K M Kaye; E D Kieff
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

5.  Epstein-Barr virus recombinants from overlapping cosmid fragments.

Authors:  B Tomkinson; E Robertson; R Yalamanchili; R Longnecker; E Kieff
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

6.  An Epstein-Barr virus with a 58-kilobase-pair deletion that includes BARF0 transforms B lymphocytes in vitro.

Authors:  E S Robertson; B Tomkinson; E Kieff
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

7.  Establishment of latent Epstein-Barr virus infection and stable episomal maintenance in murine B-cell lines.

Authors:  K M Haan; A Aiyar; R Longnecker
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

8.  Deletion of DNA encoding the first five transmembrane domains of Epstein-Barr virus latent membrane proteins 2A and 2B.

Authors:  R Longnecker; C L Miller; B Tomkinson; X Q Miao; E Kieff
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103

9.  Differential regulation of miR-21 and miR-146a by Epstein-Barr virus-encoded EBNA2.

Authors:  P Rosato; E Anastasiadou; N Garg; D Lenze; F Boccellato; S Vincenti; M Severa; E M Coccia; R Bigi; M Cirone; E Ferretti; A F Campese; M Hummel; L Frati; C Presutti; A Faggioni; P Trivedi
Journal:  Leukemia       Date:  2012-04-19       Impact factor: 11.528
  9 in total

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