Literature DB >> 837974

Increase of free arachidonic acid by furosemide in man as the cause of prostaglandin and renin release.

P C Weber, B Scherer, C Larsson.   

Abstract

Arachidonic acid (C20 :4) plasma renin activity (PRA), PGF2alpha, and sodium excretion were determined before and after furosemide in men. C20 : 4 and PRA increase (p less than 0.005) within 10 min after furosemide, PRA then decreased again whereas C20 : 4 levels remained elevated. Maximal exretion of PGF2alpha and sodium occurred 30-60 min after furosemide. Indomethacin prevented the rise of C20 : 4, PRA and PGF2alpha after furosemide, leaving sodium excretion unaltered. The release of C20 : 4 is assumed to be the primary mechanism of furosemide to increase PG biosynthesis and renin release.

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Year:  1977        PMID： 837974     DOI： 10.1016/0014-2999(77)90326-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  27 in total

1.  Prostaglandin excretion after furosemide in normal and low-renin essential hypertension.

Authors:  B Scherer; H Witzgall; P C Weber
Journal:  Klin Wochenschr       Date:  1984-08-16

2.  Contribution of prostaglandins to the systemic and renal vascular response to frusemide in normal man.

Authors:  I G Mackay; A L Muir; M L Watson
Journal:  Br J Clin Pharmacol       Date:  1984-05       Impact factor: 4.335

3.  Relationship between kallikrein and PRA after intravenous furosemide.

Authors:  G A Cinotti; G Stirati; F Taggi; R Ronci; B M Simonetti; A Pierucci
Journal:  J Endocrinol Invest       Date:  1979 Apr-Jun       Impact factor: 4.256

4.  Radioimmunoassay measurement of prostaglandins E2 and F2alpha in human urine.

Authors:  G Ciabattoni; F Pugliese; M Spaldi; G A Cinotti; C Patrono
Journal:  J Endocrinol Invest       Date:  1979 Apr-Jun       Impact factor: 4.256

5.  Arachidonic acid metabolites, hypertension and arteriosclerosis.

Authors:  P C Weber; W Siess; B Scherer; E Held; H Witzgall; R Lorenz
Journal:  Klin Wochenschr       Date:  1982-05-17

6.  [Reduced urinary prostaglandin E2-excretion and diminished responsiveness of plasma renin activity in patients with essential hypertension (author's transl)].

Authors:  B Scherer; E Held; H H Lange; P C Weber
Journal:  Klin Wochenschr       Date:  1979-06-01

7.  Effect of prostaglandin E2 on chloride transport across the rabbit thick ascending limb of Henle. Selective inhibitions of the medullary portion.

Authors:  J B Stokes
Journal:  J Clin Invest       Date:  1979-08       Impact factor: 14.808

8.  The effect of inhaled frusemide on airway sensitivity to inhaled 4.5% sodium chloride aerosol in asthmatic subjects.

Authors:  L T Rodwell; S D Anderson; J I du Toit; J P Seale
Journal:  Thorax       Date:  1993-03       Impact factor: 9.139

9.  Failure of indomethacin to impair the diuretic and natriuretic effects of the loop diuretic torasemide in healthy volunteers.

Authors:  E van Ganse; J Douchamps; F Deger; M Staroukine; A Verniory; A Herchuelz
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

10.  Formation and action of prostaglandins in the kidney.

Authors:  P C Weber; B Scherer; W Siess; E Held; J Schnermann
Journal:  Klin Wochenschr       Date:  1979-10-01
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