| Literature DB >> 8379332 |
Y Kikawa1, Y Fuji, T Takano, Y Shigematsu, M Sudo, M Okamoto, S Mizutani.
Abstract
An 8 year old girl with adult type Philadelphia (Ph1)-positive chronic myelogenous leukemia received natural alpha-interferon therapy in the chronic phase. Complete suppression of the Ph1 clone of bone marrow cells was achieved after 1 month of therapy, which was determined by disappearance of rearranged breakpoint cluster region (BCR) gene in Southern blot analysis. Complete hematological remission was also attained following 2 months of therapy. Both the suppression and the hematological remission have been sustained for 24 months with alpha-interferon, in spite of the detection of the chimeric BCR/ABL mRNA in her bone marrow by polymerase chain reaction assay 12 months after therapy.Entities:
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Year: 1993 PMID： 8379332 DOI： 10.1111/j.1442-200x.1993.tb03072.x
Source DB: PubMed Journal: Acta Paediatr Jpn ISSN： 0374-5600