Literature DB >> 8379211

The influence of ascorbic acid on selected parameters of cell immunity in guinea pigs exposed to cadmium.

J Kubová1, J Tulinská, E Stolcová, A Mosat'ová, E Ginter.   

Abstract

The study investigated the possibility of influencing immunotoxic effects of Cd through ascorbic acid. Guinea pigs with high and low intake of ascorbic acid were perorally exposed to cadmium chloride (1 mg Cd/animal/day). The daily vitamin C intake was 2 and 100 mg per animal, respectively. Phagocytic activity of polymorphonuclear leucocytes and monocytes as well as the percentage of active and total T lymphocytes in peripheral blood of animals were evaluated. Five- and 12-week experiments showed a mutual potentiation of negative effects of Cd on the immune system by suboptimal intake of ascorbic acid. Toxic effects of Cd on the immune system can be reduced by a sufficient intake of vitamin C.

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Year:  1993        PMID： 8379211     DOI： 10.1007/bf01614754

Source DB:  PubMed          Journal:  Z Ernahrungswiss        ISSN： 0044-264X


  16 in total

1.  Re: "Plasma antioxidant vitamins and subsequent cancer mortality in the 12-year follow-up of the prospective Basel study".

Authors:  E Ginter
Journal:  Am J Epidemiol       Date:  1992-03-01       Impact factor: 4.897

2.  Effects of cadmium on natural killer and killer cell functions in vivo.

Authors:  N H Stacey; G Craig; L Muller
Journal:  Environ Res       Date:  1988-02       Impact factor: 6.498

3.  Immune complex nephritis in rats induced by long-term oral exposure to cadmium.

Authors:  B C Joshi; C Dwivedi; A Powell; M Holscher
Journal:  J Comp Pathol       Date:  1981-01       Impact factor: 1.311

4.  Mode of existence of cadmium in rat liver and kidney after prolonged subcutaneous administration.

Authors:  M Sato; Y Nagai
Journal:  Toxicol Appl Pharmacol       Date:  1980-06-15       Impact factor: 4.219

5.  Immunopathology of chronic cadmium administration in mice.

Authors:  R F Borgman; B Au; R K Chandra
Journal:  Int J Immunopharmacol       Date:  1986

6.  Altered immune response during cadmium administration in mice.

Authors:  I Malavé; D T de Ruffino
Journal:  Toxicol Appl Pharmacol       Date:  1984-06-15       Impact factor: 4.219

7.  The effects of in vitro and aerosol exposures to cadmium on phagocytosis by rat pulmonary macrophages.

Authors:  B J Greenspan; P E Morrow
Journal:  Fundam Appl Toxicol       Date:  1984-02

8.  Inhibition of delayed hypersensitivity reaction in mice by cadmium.

Authors:  H Fujimaki; F Shimizu; R Kawamura; K Kubota
Journal:  Toxicol Lett       Date:  1983-12       Impact factor: 4.372

9.  Evaluation of host resistance and immune function in cadmium-exposed mice.

Authors:  P T Thomas; H V Ratajczak; C Aranyi; R Gibbons; J D Fenters
Journal:  Toxicol Appl Pharmacol       Date:  1985-09-30       Impact factor: 4.219

10.  [Effect of lead and cadmium on the viability and phagocytosis of human polymorphonuclear leukocytes].

Authors:  B Baginski
Journal:  Zentralbl Bakteriol Mikrobiol Hyg B       Date:  1985-12
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