Literature DB >> 8378301

Transgenic mouse models of lipoprotein metabolism and atherosclerosis.

J L Breslow1.   

Abstract

Lipoprotein transport genes have either been added to the germ line of mice by transgenic techniques or knocked out by homologous recombination in embryonic stem cells. The resultant over- or underexpression of these genes has resulted in new insights about how these genes function in the body and their role in lipoprotein metabolism. Either singly or in combination, these genetic modifications can be used to engineer the mouse to make it a better model for human lipoprotein disorders and atherosclerosis.

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Year:  1993        PMID： 8378301      PMCID： PMC47346          DOI： 10.1073/pnas.90.18.8314

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  35 in total

1.  LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation.

Authors:  J Herz; D E Clouthier; R E Hammer
Journal:  Cell       Date:  1992-10-30       Impact factor: 41.582

2.  Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.

Authors:  H Shimano; N Yamada; M Katsuki; K Yamamoto; T Gotoda; K Harada; M Shimada; Y Yazaki
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

3.  Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia.

Authors:  A M van den Maagdenberg; M H Hofker; P J Krimpenfort; I de Bruijn; B van Vlijmen; H van der Boom; L M Havekes; R R Frants
Journal:  J Biol Chem       Date:  1993-05-15       Impact factor: 5.157

4.  A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice.

Authors:  W S Simonet; N Bucay; S J Lauer; J M Taylor
Journal:  J Biol Chem       Date:  1993-04-15       Impact factor: 5.157

5.  Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3' to the gene in the promoter of the adjacent convergently transcribed apoC-III gene.

Authors:  A Walsh; N Azrolan; K Wang; A Marcigliano; A O'Connell; J L Breslow
Journal:  J Lipid Res       Date:  1993-04       Impact factor: 5.922

6.  Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a).

Authors:  G Chiesa; H H Hobbs; M L Koschinsky; R M Lawn; S D Maika; R E Hammer
Journal:  J Biol Chem       Date:  1992-12-05       Impact factor: 5.157

7.  Dietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and apolipoprotein (Apo) A-I. Presentation of a new animal model and mechanistic studies in human Apo A-I transgenic and control mice.

Authors:  T Hayek; Y Ito; N Azrolan; R B Verdery; K Aalto-Setälä; A Walsh; J L Breslow
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808

8.  Atherogenesis in transgenic mice expressing human apolipoprotein(a)

Authors:  R M Lawn; D P Wade; R E Hammer; G Chiesa; J G Verstuyft; E M Rubin
Journal:  Nature       Date:  1992-12-17       Impact factor: 49.962

9.  Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles.

Authors:  K Aalto-Setälä; E A Fisher; X Chen; T Chajek-Shaul; T Hayek; R Zechner; A Walsh; R Ramakrishnan; H N Ginsberg; J L Breslow
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

10.  High level expression of human apolipoprotein A-I in transgenic rats raises total serum high density lipoprotein cholesterol and lowers rat apolipoprotein A-I.

Authors:  M E Swanson; T E Hughes; I S Denny; D S France; J R Paterniti; C Tapparelli; P Gfeller; K Bürki
Journal:  Transgenic Res       Date:  1992-05       Impact factor: 2.788
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  24 in total

1.  Stage-specific remodeling of atherosclerotic lesions upon cholesterol lowering in LDL receptor knockout mice.

Authors:  Ying Zhao; Dan Ye; Jun Wang; Laura Calpe-Berdiel; Saaleha B R N Azzis; Theo J C Van Berkel; Miranda Van Eck
Journal:  Am J Pathol       Date:  2011-07-08       Impact factor: 4.307

Review 2.  Genes and physiology: molecular physiology in genetically engineered animals.

Authors:  K R Chien
Journal:  J Clin Invest       Date:  1996-02-15       Impact factor: 14.808

Review 3.  Lipoproteins and their functions.

Authors:  A J Habenicht; U Janssen-Timmen; R Ziegler; G Schettler
Journal:  Clin Investig       Date:  1994-09

Review 4.  High-density lipoprotein and atherosclerosis regression: evidence from preclinical and clinical studies.

Authors:  Jonathan E Feig; Bernd Hewing; Jonathan D Smith; Stanley L Hazen; Edward A Fisher
Journal:  Circ Res       Date:  2014-01-03       Impact factor: 17.367

5.  Historical perspective: phosphatidylserine and phosphatidylethanolamine from the 1800s to the present.

Authors:  Jean E Vance
Journal:  J Lipid Res       Date:  2018-04-16       Impact factor: 5.922

6.  Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice.

Authors:  L Berthou; N Duverger; F Emmanuel; S Langouët; J Auwerx; A Guillouzo; J C Fruchart; E Rubin; P Denèfle; B Staels; D Branellec
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

Review 7.  The fat-fed apolipoprotein E knockout mouse brachiocephalic artery in the study of atherosclerotic plaque rupture.

Authors:  Andrew R Bond; Christopher L Jackson
Journal:  J Biomed Biotechnol       Date:  2010-11-07

8.  The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages.

Authors:  Margarita de la Llera-Moya; Denise Drazul-Schrader; Bela F Asztalos; Marina Cuchel; Daniel J Rader; George H Rothblat
Journal:  Arterioscler Thromb Vasc Biol       Date:  2010-01-14       Impact factor: 8.311

9.  Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.

Authors:  S H Zhang; R L Reddick; B Burkey; N Maeda
Journal:  J Clin Invest       Date:  1994-09       Impact factor: 14.808

10.  Mouse model of venous bypass graft arteriosclerosis.

Authors:  Y Zou; H Dietrich; Y Hu; B Metzler; G Wick; Q Xu
Journal:  Am J Pathol       Date:  1998-10       Impact factor: 4.307
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