Literature DB >> 8377947

alpha-Methylprednisolone promotes skeletal myogenesis in dystrophin-deficient and control mouse cultures.

L Metzinger1, A C Passaquin, J M Warter, P Poindron.   

Abstract

We have examined the influence of the glucocorticoid alpha-methylprednisolone (PDN) on the morphological differentiation of skeletal muscle cells derived from dystrophin-deficient C57BL/10 mdx, congenic C57BL/10 and allogenic Balb/c newborn mice. We show that PDN enhances myogenic cell numbers in dystrophin-deficient cultures as well as in matched controls. A parallel increase in the fusion rate of myoblasts into myotubes occurs while the size of myotubes, as determined by nuclei per myotube, is slightly increased. This promoting effect of PDN on myogenesis could be related to the enhanced muscular function observed in PDN-treated Duchenne's muscular dystrophy-affected boys.

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Year:  1993        PMID： 8377947     DOI： 10.1016/0304-3940(93)90700-u

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  5 in total

1.  An image analysis method for the precise selection and quantitation of fluorescently labeled cellular constituents: application to the measurement of human muscle cells in culture.

Authors:  Chibeza C Agley; Cristiana P Velloso; Norman R Lazarus; Stephen D R Harridge
Journal:  J Histochem Cytochem       Date:  2012-04-17       Impact factor: 2.479

2.  A rapid preparation of primary cultures of mouse skeletal muscle cells.

Authors:  L Metzinger; P Poindron; A C Passaquin
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

3.  Regulation of cytosolic calcium in skeletal muscle cells of the mdx mouse under conditions of stress.

Authors:  W J Leijendekker; A C Passaquin; L Metzinger; U T Rüegg
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

4.  Effects of prednisolone on skeletal muscle contractility in mdx mice.

Authors:  Kristen A Baltgalvis; Jarrod A Call; Jason B Nikas; Dawn A Lowe
Journal:  Muscle Nerve       Date:  2009-09       Impact factor: 3.217

5.  Modulation by prednisolone of calcium handling in skeletal muscle cells.

Authors:  L Metzinger; A C Passaquin; W J Leijendekker; P Poindron; U T Rüegg
Journal:  Br J Pharmacol       Date:  1995-12       Impact factor: 8.739
  5 in total

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