Literature DB >> 8377203

Human deoxyhaemoglobin-2,3-diphosphoglycerate complex low-salt structure at 2.5 A resolution.

V Richard1, G G Dodson, Y Mauguen.   

Abstract

The haemoglobin-2,3-diphosphoglycerate complex structure has been solved at 2.5 A resolution using crystals grown from low-salt solutions. The results show some important differences with the precedent haemoglobin-2,3-diphosphoglycerate high-salt structure solved by Arnone. First, we observe a loss of symmetry in the binding site, secondly both of the lysine residues 82 beta interact with 2,3-diphosphoglycerate at the same time, each making two contacts. This level of interaction is in agreement with the functional behaviour of natural haemoglobin mutants with mutations at the 2,3-diphosphoglycerate binding site.

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Year:  1993        PMID： 8377203     DOI： 10.1006/jmbi.1993.1505

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  22 in total

1.  Heterotropic effectors exert more significant strain on monoligated than on unligated hemoglobin.

Authors:  M Coletta; M Angeletti; I Ascone; G Boumis; A C Castellano; M Dell'Ariccia; S Della Longa; G De Sanctis; A M Priori; R Santucci; A Feis; G Amiconi
Journal:  Biophys J       Date:  1999-03       Impact factor: 4.033

2.  Electrochemical investigation of the effect of some organic phosphates on haemoglobin.

Authors:  S Rezaei-Zarchi; A A Saboury; H Ghourchian; J Hong; A Barzegar; P Norouzi; A A Moosavi-Movahedi; M R Ganjali; A Javed
Journal:  J Biosci       Date:  2007-03       Impact factor: 1.826

3.  Crystallographic characterization of the nitric oxide derivative of R-state human hemoglobin.

Authors:  Jun Yi; Alexei S Soares; George B Richter-Addo
Journal:  Nitric Oxide       Date:  2014-04-22       Impact factor: 4.427

4.  Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents.

Authors:  A M Omar; M A Mahran; M S Ghatge; N Chowdhury; F H A Bamane; M E El-Araby; O Abdulmalik; M K Safo
Journal:  Org Biomol Chem       Date:  2015-06-14       Impact factor: 3.876

5.  Structure and function of crocodilian hemoglobins and allosteric regulation by chloride, ATP, and CO2.

Authors:  Angela Fago; Chandrasekhar Natarajan; Martín Pettinati; Federico G Hoffmann; Tobias Wang; Roy E Weber; Salvador I Drusin; Federico Issoglio; Marcelo A Martí; Darío Estrin; Jay F Storz
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2020-02-05       Impact factor: 3.619

6.  Enthalpic consequences of reduced chloride binding in Andean frog (Telmatobius peruvianus) hemoglobin.

Authors:  Roy E Weber
Journal:  J Comp Physiol B       Date:  2014-03-28       Impact factor: 2.200

7.  Molecular dynamics analysis of a second phosphate site in the hemoglobins of the seabird, south polar skua. Is there a site-site migratory mechanism along the central cavity?

Authors:  A Riccio; M Tamburrini; B Giardina; G di Prisco
Journal:  Biophys J       Date:  2001-10       Impact factor: 4.033

Review 8.  Therapeutic strategies to alter the oxygen affinity of sickle hemoglobin.

Authors:  Martin K Safo; Gregory J Kato
Journal:  Hematol Oncol Clin North Am       Date:  2014-01-21       Impact factor: 3.722

9.  Molecular dynamics simulations of hemoglobin A in different states and bound to DPG: effector-linked perturbation of tertiary conformations and HbA concerted dynamics.

Authors:  Monique Laberge; Takashi Yonetani
Journal:  Biophys J       Date:  2007-12-20       Impact factor: 4.033

10.  Normal coordinate structural decomposition of the heme distortions of hemoglobin in various quaternary states and bound to allosteric effectors.

Authors:  Monique Laberge; Takashi Yonetani; Judit Fidy
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943
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