| Literature DB >> 8376820 |
V Schauf1, W N Rom, K A Smith, E P Sampaio, P A Meyn, J M Tramontana, Z A Cohn, G Kaplan.
Abstract
Selected parameters of cellular immunity relating to cytokine gene activation and responsiveness to interleukin-2 (IL-2) were analyzed in 27 patients with active pulmonary tuberculosis and no human immunodeficiency virus type 1 infection. Cytokine mRNAs were not expressed by peripheral blood mononuclear cells (PBMC) of normal controls. In PBMC of tuberculosis patients, messages for IL-1, IL-8, and tumor necrosis factor-alpha were uniformly expressed, whereas PBMC of only 5 of 18 patients expressed IL-6. PBMC of 7 patients (all of those with systemic symptoms) expressed interferon-gamma mRNA and none expressed IL-2 mRNA. Most patients' cells demonstrated IL-4 mRNA. Limiting dilution analysis of IL-2-responsive cells in PBMC revealed that tuberculosis patients had 10-fold fewer IL-2-responsive cells than did controls.Entities:
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Year: 1993 PMID： 8376820 DOI： 10.1093/infdis/168.4.1056
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226