| Literature DB >> 8374940 |
M Nicolodi1, F Sicuteri, M Poggioni.
Abstract
A slow-release gonadotropin-releasing hormone (Gn-RH) analogue was administered to 30 males suffering from chronic cluster headache (CH) in a placebo-controlled study with the aim of enhancing neurotransmission in the pain-suppressing systems of the hypothalamus through a feedback action involving neuroendocrine functions too. A significant improvement in the severity of the pain occurred together with the expected lowering of the libido and serum levels of testosterone and luteinizing hormone. We postulate that the benefit of the Gn-RH analogue relates to an impairment of neuronal modulation in cluster headache.Entities:
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Year: 1993 PMID： 8374940 DOI： 10.1046/j.1468-2982.1993.1304253.x
Source DB: PubMed Journal: Cephalalgia ISSN： 0333-1024 Impact factor: 6.292