Literature DB >> 8374766

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.

J Q Trojanowski1, M Mawal-Dewan, M L Schmidt, J Martin, V M Lee.   

Abstract

The phosphorylation of normal tau by mitogen activated protein (MAP) or extracellular signal related kinases (ERKs) induces tau to acquire biochemical properties of Alzheimer's disease (AD) paired helical filament (PHF) proteins in vitro. We show here that a monoclonal antibody to MAP kinases recognizes ERK2 in normal and AD cortex, but ERK2 levels are slightly reduced in the AD brain. Since ERK2 was detected in neurofibrillary tangles and senile plaque neurites in the AD hippocampus, ERK2 is positioned to phosphorylate normal tau and could play a role in the generation of PHFs in AD.

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Year:  1993        PMID： 8374766     DOI： 10.1016/0006-8993(93)91286-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  18 in total

1.  Chronic CXCL10 alters the level of activated ERK1/2 and transcriptional factors CREB and NF-kappaB in hippocampal neuronal cell culture.

Authors:  Hilda Bajova; Thomas E Nelson; Donna L Gruol
Journal:  J Neuroimmunol       Date:  2008-03-10       Impact factor: 3.478

2.  The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome.

Authors:  Jerzy Wegiel; Karol Dowjat; Wojciech Kaczmarski; Izabela Kuchna; Krzysztof Nowicki; Janusz Frackowiak; Bozena Mazur Kolecka; Jarek Wegiel; Wayne P Silverman; Barry Reisberg; Mony Deleon; Thomas Wisniewski; Cheng-Xin Gong; Fei Liu; Tatyana Adayev; Mo-Chou Chen-Hwang; Yu-Wen Hwang
Journal:  Acta Neuropathol       Date:  2008-08-12       Impact factor: 17.088

3.  A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.

Authors:  T Kawamata; T Taniguchi; H Mukai; M Kitagawa; T Hashimoto; K Maeda; Y Ono; C Tanaka
Journal:  J Neurosci       Date:  1998-09-15       Impact factor: 6.167

4.  Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments.

Authors:  W K Liu; R T Williams; F L Hall; D W Dickson; S H Yen
Journal:  Am J Pathol       Date:  1995-01       Impact factor: 4.307

Review 5.  Paired helical filament tau in Alzheimer's disease. The kinase connection.

Authors:  J Q Trojanowski; V M Lee
Journal:  Am J Pathol       Date:  1994-03       Impact factor: 4.307

6.  Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease.

Authors:  B T Hyman; T E Elvhage; J Reiter
Journal:  Am J Pathol       Date:  1994-03       Impact factor: 4.307

Review 7.  The role of DYRK1A in neurodegenerative diseases.

Authors:  Jerzy Wegiel; Cheng-Xin Gong; Yu-Wen Hwang
Journal:  FEBS J       Date:  2010-12-13       Impact factor: 5.542

Review 8.  Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism.

Authors:  D Allan Butterfield; Miranda L Bader Lange
Journal:  J Neurochem       Date:  2009-09-23       Impact factor: 5.372

9.  Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

Authors:  S M Greenberg; E H Koo; D J Selkoe; W Q Qiu; K S Kosik
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-19       Impact factor: 11.205

10.  PPARγ recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement.

Authors:  Jordan B Jahrling; Caterina M Hernandez; Larry Denner; Kelly T Dineley
Journal:  J Neurosci       Date:  2014-03-12       Impact factor: 6.167
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