Literature DB >> 8374510

A GM-CSF/IL-3 fusion protein promotes neutrophil and platelet recovery in sublethally irradiated rhesus monkeys.

D E Williams1, J T Dunn, L S Park, E A Frieden, F R Seiler, A M Farese, T J Macvittie.   

Abstract

The effects of a human GM-CSF/IL-3 fusion protein (PIXY321) were examined in a primate model of rebound hematopoiesis following sublethal irradiation. The results demonstrated an enhanced rate of both neutrophil and platelet regeneration, as well as functional activation of circulating neutrophils.

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Year:  1993        PMID： 8374510

Source DB:  PubMed          Journal:  Biotechnol Ther        ISSN： 0898-2848


  3 in total

1.  Preparation of a recombinant chimaera of insulin-like growth factor II and interleukin 3 with high proliferative potency for haemopoietic cells.

Authors:  M R Difalco; L F Congote
Journal:  Biochem J       Date:  1997-09-01       Impact factor: 3.857

2.  Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia.

Authors:  A M Farese; P Hunt; L B Grab; T J MacVittie
Journal:  J Clin Invest       Date:  1996-05-01       Impact factor: 14.808

3.  Early Mixed Lymphoid Donor/Host Chimerism is Associated with Improved Transplant Outcome in Patients with Primary or Secondary Myelofibrosis.

Authors:  H Joachim Deeg; Rachel B Salit; Tim Monahan; Gary Schoch; Chris McFarland; Bart L Scott; Barry E Storer
Journal:  Biol Blood Marrow Transplant       Date:  2020-07-18       Impact factor: 5.742
  3 in total

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