Literature DB >> 8373366

Ricin induces the production of tumour necrosis factor-alpha and interleukin-1 beta by human peripheral-blood mononuclear cells.

F Licastro1, M C Morini, A Bolognesi, F Stirpe.   

Abstract

Ricin induced the release of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta by human peripheral-blood mononuclear cells in a dose- and time-dependent manner. The inhibition induced by ricin upon the phytohaemagglutinin (PHA)-driven lymphocyte proliferation was greater in cultures of mononuclear cells than that observed in monocyte-free cultures of lymphocytes, and was decreased after addition of an anti-TNF-alpha antibody to PHA-activated cultures. Low levels of TNF-alpha were detected in plasma from rats poisoned with ricin. These results suggest that ricin induced the release of macrophage-derived cytokines which may have a role in the pathogenesis of ricin toxic effects.

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Year:  1993        PMID： 8373366      PMCID： PMC1134485          DOI： 10.1042/bj2940517

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  29 in total

Review 1.  Interleukin-1 and its biologically related cytokines.

Authors:  C A Dinarello
Journal:  Adv Immunol       Date:  1989       Impact factor: 3.543

2.  Involvement of tumor necrosis factor-alpha in development of hepatic injury in galactosamine-sensitized mice.

Authors:  I Hishinuma; J Nagakawa; K Hirota; K Miyamoto; K Tsukidate; T Yamanaka; K Katayama; I Yamatsu
Journal:  Hepatology       Date:  1990-11       Impact factor: 17.425

3.  Induction of tumor necrosis factor expression by a lectin from Viscum album.

Authors:  D N Männel; H Becker; A Gundt; A Kist; H Franz
Journal:  Cancer Immunol Immunother       Date:  1991       Impact factor: 6.968

4.  Effect of ricin on acute phase response in rats.

Authors:  G D Nadkarni; U R Deshpande
Journal:  Indian J Exp Biol       Date:  1991-06       Impact factor: 0.818

5.  The effect of the castor bean toxin, ricin, on rat IgE and IgG responses.

Authors:  S C Thorpe; R D Murdoch; D M Kemeny
Journal:  Immunology       Date:  1989-11       Impact factor: 7.397

6.  Effect of ricin on the proliferation of rat spleen and mesenteric lymph node cells.

Authors:  D M Kemeny; S C Thorpe; P G Holt
Journal:  Int Arch Allergy Appl Immunol       Date:  1989

7.  Increased secretion of tumor necrosis factors alpha, interleukin 1, and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract.

Authors:  T Hajto; K Hostanska; K Frei; C Rordorf; H J Gabius
Journal:  Cancer Res       Date:  1990-06-01       Impact factor: 12.701

8.  Interactions of ricin with sinusoidal endothelial rat liver cells. Different involvement of two distinct carbohydrate-specific mechanisms in surface binding and internalization.

Authors:  S Magnusson; T Berg; E Turpin; J P Frénoy
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857

9.  Inhibition of protein synthesis enhances the lytic effects of tumor necrosis factor alpha and interferon gamma in cell lines derived from gynecological malignancies.

Authors:  L S Massad; D G Mutch; M S Kao; C B Powell; J L Collins
Journal:  Cancer Immunol Immunother       Date:  1991       Impact factor: 6.968

10.  Differences in the synthesis and kinetics of release of interleukin 1 alpha, interleukin 1 beta and tumor necrosis factor from human mononuclear cells.

Authors:  G Lonnemann; S Endres; J W Van der Meer; J G Cannon; K M Koch; C A Dinarello
Journal:  Eur J Immunol       Date:  1989-09       Impact factor: 5.532
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  12 in total

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Authors:  Xue Jun Fu; Kazumoto Iijima; Kandai Nozu; Kiyoshi Hamahira; Ryojiro Tanaka; Tatsuya Oda; Norishige Yoshikawa; Masafumi Matsuo
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3.  Purified Shiga-like toxins induce expression of proinflammatory cytokines from murine peritoneal macrophages.

Authors:  V L Tesh; B Ramegowda; J E Samuel
Journal:  Infect Immun       Date:  1994-11       Impact factor: 3.441

4.  Pathology of lethal and sublethal doses of aerosolized ricin in rhesus macaques.

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Journal:  Toxicol Pathol       Date:  2013-06-11       Impact factor: 1.902

Review 5.  [Protein-carbohydrate recognition. Foundation and medical application with illustrations of tumor lectin studies].

Authors:  H J Gabius; K Kayser; S Gabius
Journal:  Naturwissenschaften       Date:  1995-12

Review 6.  The interactions of human neutrophils with shiga toxins and related plant toxins: danger or safety?

Authors:  Maurizio Brigotti
Journal:  Toxins (Basel)       Date:  2012-03-01       Impact factor: 4.546

7.  Production of Active Nonglycosylated Recombinant B-Chain of Type-2 Ribosome-Inactivating Protein from Viscum articulatum and Its Biological Effects on Peripheral Blood Mononuclear Cells.

Authors:  Tzu-Li Lu; Jing-Yuan Chuang; Jai-Sing Yang; Shau-Ting Chiu; Nai-Wan Hsiao; Mei-Chen Wu; Shih-Hsiung Wu; Ching-Hsiang Hsu
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8.  Role of the mannose receptor (CD206) in innate immunity to ricin toxin.

Authors:  Emily Gage; Maria O Hernandez; Joanne M O'Hara; Elizabeth A McCarthy; Nicholas J Mantis
Journal:  Toxins (Basel)       Date:  2011-09-09       Impact factor: 4.546

9.  Ribosome-Inactivating Protein α-Momorcharin Derived from Edible Plant Momordica charantia Induces Inflammatory Responses by Activating the NF-kappaB and JNK Pathways.

Authors:  Ying-Jie Chen; Jia-Qian Zhu; Xiu-Qiong Fu; Tao Su; Ting Li; Hui Guo; Pei-Li Zhu; Sally Kin-Wah Lee; Hua Yu; Anfernee Kai-Wing Tse; Zhi-Ling Yu
Journal:  Toxins (Basel)       Date:  2019-11-26       Impact factor: 4.546

Review 10.  Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties.

Authors:  Jia-Qi Lu; Zhen-Ning Zhu; Yong-Tang Zheng; Pang-Chui Shaw
Journal:  Toxins (Basel)       Date:  2020-03-09       Impact factor: 4.546
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