Literature DB >> 8372926

Intratympanic gentamicin instillation as treatment of unilateral Menière's disease: update of an ongoing study.

J M Nedzelski1, C M Chiong, G Fradet, D A Schessel, G E Bryce, A G Pfleiderer.   

Abstract

A prospective study using intratympanic gentamicin instillation as treatment for disabling unilateral Meniere's disease has been ongoing at our institution for 4 years. Treatment effectiveness is evaluated based on the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) 1985 guidelines. This report is based on 30 patients who have become eligible for assessment. We conclude that gentamicin intratympanic instillation as currently used in our protocol is an effective, safe, and easily administered method of achieving a predictable measure of vertigo control.

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Year:  1993        PMID: 8372926

Source DB:  PubMed          Journal:  Am J Otol        ISSN: 0192-9763


  13 in total

1.  Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols.

Authors:  Alec N Salt; Ruth M Gill; Stefan K Plontke
Journal:  Laryngoscope       Date:  2008-10       Impact factor: 3.325

Review 2.  Ménière's disease.

Authors:  S N Merchant; S D Rauch; J B Nadol
Journal:  Eur Arch Otorhinolaryngol       Date:  1995       Impact factor: 2.503

3.  Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis.

Authors:  Chenkai Dai; Gene Y Fridman; Natan S Davidovics; Bryce Chiang; Joong Ho Ahn; Charles C Della Santina
Journal:  Hear Res       Date:  2011-08-26       Impact factor: 3.208

4.  current opinion: Intratympanic gentamicin therapy for meniere's disease.

Authors:  A K Bhattacharyya
Journal:  Indian J Otolaryngol Head Neck Surg       Date:  1997-04

5.  Intratympanic gentamicin therapy for meniere's disease.

Authors:  A K Bhattacharyya
Journal:  Indian J Otolaryngol Head Neck Surg       Date:  1997-03

6.  Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig.

Authors:  A N Salt; J J Hartsock; R M Gill; E King; F B Kraus; S K Plontke
Journal:  Hear Res       Date:  2016-10-08       Impact factor: 3.208

Review 7.  Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications.

Authors:  Alec N Salt; Stefan K Plontke
Journal:  Hear Res       Date:  2018-03-11       Impact factor: 3.208

8.  Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation.

Authors:  Corey S Frucht; Mohamed Uduman; Jamie L Duke; Steven H Kleinstein; Joseph Santos-Sacchi; Dhasakumar S Navaratnam
Journal:  PLoS One       Date:  2010-07-09       Impact factor: 3.240

9.  Is surgical vestibular ablation necessary in disabling peripheral vertigo?

Authors:  A Mahadevaiah; Bhavin Parikh
Journal:  Indian J Otolaryngol Head Neck Surg       Date:  2008-04-03

10.  Intratympanic (IT) Therapies for Menière's Disease: Some Consensus Among the Confusion.

Authors:  Desi P Schoo; Grace X Tan; Matthew R Ehrenburg; Seth E Pross; Bryan K Ward; John P Carey
Journal:  Curr Otorhinolaryngol Rep       Date:  2017-05-03
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