Literature DB >> 8372406

Signalling properties of lysophosphatidic acid.

M E Durieux1, K R Lynch.   

Abstract

Lysophosphatidic acid (LPA) is the simplest natural phospholipid, primarily known as a membrane component and metabolic intermediate. However, a remarkable variety of biological effects of this compound have come to light, seemingly pointing to an additional role for LPA as a signalling molecule. In this review, Marcel Durieux and Kevin Lynch integrate the recent information that indicates that LPA could be an intercellular messenger, possibly acting through a G protein-coupled receptor, and with a role in cell growth and motility.

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Year:  1993        PMID： 8372406     DOI： 10.1016/0165-6147(93)90021-b

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  26 in total

1.  Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation.

Authors:  K W Young; R A Challiss; S R Nahorski; J J MacKrill
Journal:  Biochem J       Date:  1999-10-01       Impact factor: 3.857

2.  Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling.

Authors:  Chananat Klomsiri; LeAnn C Rogers; Laura Soito; Anita K McCauley; S Bruce King; Kimberly J Nelson; Leslie B Poole; Larry W Daniel
Journal:  Free Radic Biol Med       Date:  2014-03-21       Impact factor: 7.376

3.  Calcium homeostasis in mouse fibroblast cells: affected by U-73122, a putative phospholipase C beta blocker, via multiple mechanisms.

Authors:  J P Grierson; J Meldolesi
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

4.  Cloning and expression analysis of murine phospholipase D1.

Authors:  W C Colley; Y M Altshuller; C K Sue-Ling; N G Copeland; D J Gilbert; N A Jenkins; K D Branch; S E Tsirka; R J Bollag; W B Bollag; M A Frohman
Journal:  Biochem J       Date:  1997-09-15       Impact factor: 3.857

5.  Roles of atypical protein kinase C in lysophosphatidic acid-induced type II adenylyl cyclase activation in RAW 264.7 macrophages.

Authors:  W W Lin; S H Chang; S M Wang
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

6.  Platelet phospholipase D is activated by protein kinase C via an integrin alpha IIb beta 3-independent mechanism.

Authors:  E A Martinson; S Scheible; A Greinacher; P Presek
Journal:  Biochem J       Date:  1995-09-01       Impact factor: 3.857

7.  Adenylate cyclase, cyclic AMP and extracellular-signal-regulated kinase-2 in airway smooth muscle: modulation by protein kinase C and growth serum.

Authors:  N Moughal; P A Stevens; D Kong; S Pyne; N J Pyne
Journal:  Biochem J       Date:  1995-03-15       Impact factor: 3.857

8.  The binding of natural and fluorescent lysophospholipids to wild-type and mutant rat liver fatty acid-binding protein and albumin.

Authors:  A E Thumser; D C Wilton
Journal:  Biochem J       Date:  1995-04-01       Impact factor: 3.857

9.  Metal-ion stimulation and inhibition of lysophospholipase D which generates bioactive lysophosphatidic acid in rat plasma.

Authors:  A Tokumura; M Miyake; O Yoshimoto; M Shimizu; K Fukuzawa
Journal:  Lipids       Date:  1998-10       Impact factor: 1.880

10.  Receptor-mediated vascular smooth muscle migration induced by LPA involves p38 mitogen-activated protein kinase pathway activation.

Authors:  Zhi-Bin Zhou; Jian-Ping Niu; Zhi-Jun Zhang
Journal:  Int J Mol Sci       Date:  2009-07-13       Impact factor: 6.208
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