Literature DB >> 8372352

Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association.

I T Chan1, A Limmer, M C Louie, E D Bullock, W P Fung-Leung, T W Mak, D Y Loh.   

Abstract

The CD8 alpha cytoplasmic domain associates with p56lck, a nonreceptor protein-tyrosine kinase. The biological relevance of CD8 alpha-Lck association in T cell development was tested with transgenic mice generated to express a CD8 alpha molecule with two amino acid substitutions in its cytoplasmic domain, which abolishes the association of CD8 alpha with Lck. The CD8 alpha mutant was analyzed in a CD8-/- background and in the context of the transgenic 2C T cell receptor. The development and function of CD8+ T cells in these mice were apparently normal. Thus, CD8 alpha-Lck association is not necessary for positive selection, negative selection, or CD8-dependent cytotoxic function.

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Year:  1993        PMID： 8372352     DOI： 10.1126/science.8372352

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

1.  CD4 regulates the efficiency of an endogenous superantigen-induced clonal deletion of TCRV beta 11+ cells in the periphery.

Authors:  S Kubo; A Hasegawa; K Hashimoto; C Shimizu; M Kubo; T Tada; T Nakayama
Journal:  Immunology       Date:  1997-12       Impact factor: 7.397

2.  Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection.

Authors:  K Hashimoto; S J Sohn; S D Levin; T Tada; R M Perlmutter; T Nakayama
Journal:  J Exp Med       Date:  1996-09-01       Impact factor: 14.307

3.  Apoptosis and interleukin 7 gene expression in chronic B-lymphocytic leukemia cells.

Authors:  B W Long; P L Witte; G N Abraham; S A Gregory; J M Plate
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

4.  Resting and activated T cells display different requirements for CD8 molecules.

Authors:  Z Cai; J Sprent
Journal:  J Exp Med       Date:  1994-06-01       Impact factor: 14.307

5.  Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position.

Authors:  Rui Wang; Kannan Natarajan; David H Margulies
Journal:  J Immunol       Date:  2009-07-22       Impact factor: 5.422

6.  Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.

Authors:  J Gratiot-Deans; R Merino; G Nuñez; L A Turka
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-25       Impact factor: 11.205

7.  Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.

Authors:  Miwa Sasai; Ji Su Ma; Masaaki Okamoto; Kohei Nishino; Hikaru Nagaoka; Eizo Takashima; Ariel Pradipta; Youngae Lee; Hidetaka Kosako; Pann-Ghill Suh; Masahiro Yamamoto
Journal:  J Exp Med       Date:  2021-05-10       Impact factor: 14.307

8.  CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity.

Authors:  H Y Irie; K S Ravichandran; S J Burakoff
Journal:  J Exp Med       Date:  1995-04-01       Impact factor: 14.307

9.  An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4.

Authors:  Henry Kao; Paul M Allen
Journal:  J Exp Med       Date:  2005-01-03       Impact factor: 14.307

10.  Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment.

Authors:  B F Haynes; C S Heinly
Journal:  J Exp Med       Date:  1995-04-01       Impact factor: 14.307
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