PURPOSE: To study the safety, effectiveness, predictability, and stability of excimer laser photorefractive keratectomy (PRK) in 133 normally sighted eyes. METHODS: An excimer laser was used with a fluence of 160 mJ/cm2 at a frequency of 5 Hz and an ablation zone of 5.0 mm. The effects of nitrogen purge at surgery and postoperative steroids were evaluated. RESULTS: No significant complications occurred in any patient. After an initial over-correction, the refraction stabilized. The average results obtained at 6 months were maintained on successive examinations to 36 months. Analysis of their visual acuity in groups IIA, IIB, and III indicates that results at 6 months are predictive of final results at 1 to 3 years (P < 0.0001; r > 0.9). In myopia (1.00-6.00 diopters [D]) treated with the excimer laser, there was a trend toward improvement in results over the course of the study. In 60% in group IIA, 58% in group IIB, 71% in group III, and 88% in group III no nitrogen (no N2), +/- 1 D was obtained. For 20/40 or better uncorrected visual acuity, the outcome was 70% for group IIA, 67% for group IIB, 75% for group III, and 100% for group III no N2. Significant improvement was noted without nitrogen purge. No significant improvement was observed from steroid treatment as used. CONCLUSION: In reducing myopia, PRK appears to be safe and effective. The results obtained are reasonably predictable and stable after 6 months. As more refinements are introduced, this procedure could become one of the most promising in refractive surgery.
PURPOSE: To study the safety, effectiveness, predictability, and stability of excimer laser photorefractive keratectomy (PRK) in 133 normally sighted eyes. METHODS: An excimer laser was used with a fluence of 160 mJ/cm2 at a frequency of 5 Hz and an ablation zone of 5.0 mm. The effects of nitrogen purge at surgery and postoperative steroids were evaluated. RESULTS: No significant complications occurred in any patient. After an initial over-correction, the refraction stabilized. The average results obtained at 6 months were maintained on successive examinations to 36 months. Analysis of their visual acuity in groups IIA, IIB, and III indicates that results at 6 months are predictive of final results at 1 to 3 years (P < 0.0001; r > 0.9). In myopia (1.00-6.00 diopters [D]) treated with the excimer laser, there was a trend toward improvement in results over the course of the study. In 60% in group IIA, 58% in group IIB, 71% in group III, and 88% in group III no nitrogen (no N2), +/- 1 D was obtained. For 20/40 or better uncorrected visual acuity, the outcome was 70% for group IIA, 67% for group IIB, 75% for group III, and 100% for group III no N2. Significant improvement was noted without nitrogen purge. No significant improvement was observed from steroid treatment as used. CONCLUSION: In reducing myopia, PRK appears to be safe and effective. The results obtained are reasonably predictable and stable after 6 months. As more refinements are introduced, this procedure could become one of the most promising in refractive surgery.