Literature DB >> 837060

Immediate effects of tobramycin on human cochlea and correlation with serum tobramycin levels.

P Wilson, R T Ramsden.   

Abstract

Electrocochleography was performed on three patients to monitor the intravenous administration of tobramycin. When peak serum tobramycin levels exceeded 8-10 mug/ml an immediate dramatic reduction in cochlear output was observed, which recovered fully as serum levels fell. The patients had no auditory or vestibular symptoms either during or after treatment.

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Year:  1977        PMID： 837060      PMCID： PMC1604140          DOI： 10.1136/bmj.1.6056.259

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  11 in total

1.  GENTAMICIN SULFATE, NEW ANTIBIOTIC AGAINST GRAM-NEGATIVE BACILLI. LABORATORY, PHARMACOLOGICAL, AND CLINICAL EVALUATION.

Authors:  R L JAO; G G JACKSON
Journal:  JAMA       Date:  1964-09-14       Impact factor: 56.272

2.  THE MECHANISM OF THE NEUROMUSCULAR BLOCKADE BY ANTIBIOTICS.

Authors:  P KUBIKOWSKI; Z SZRENIAWSKI
Journal:  Arch Int Pharmacodyn Ther       Date:  1963-12-01

3.  SUPPRESSION AND RESTORATION OF THE MICROPHONIC OUTPUT FROM THE LATERAL LINE ORGAN AFTER LOCAL APPLICATION OF STREPTOMYCIN.

Authors:  J WERSAELL; A FLOCK
Journal:  Life Sci (1962)       Date:  1964-10

4.  The curariform action of streptomycin.

Authors:  O V BRAZIL; A P CORRADO
Journal:  J Pharmacol Exp Ther       Date:  1957-08       Impact factor: 4.030

5.  Outer hair cell loss and alterations in glycogen due to tobramycin sulfate.

Authors:  D S Postma; J B Pecorak; J Prazma; S S Logue; N D Fischer
Journal:  Arch Otolaryngol       Date:  1976-03

6.  Possible effects of various ototoxic drugs upon the ATP-hydrolyzing system in the stria vascularis and spiral ligament of the guinea pig.

Authors:  T Iinuma; O Mizukoshi; J F Daly
Journal:  Laryngoscope       Date:  1967-02       Impact factor: 3.325

7.  Calcium binding as a property of kanamycin.

Authors:  L M Crawford; J M Bowen
Journal:  Am J Vet Res       Date:  1971-02       Impact factor: 1.156

8.  Observation of click-evoked compound VIII nerve responses before, during, and over seven months after kanamycin treatment in the guinea pig.

Authors:  J M Aran; J Darrouzet
Journal:  Acta Otolaryngol       Date:  1975 Jan-Feb       Impact factor: 1.494

9.  Oxygen consumption in normal and kanamycin damaged cochleae.

Authors:  O Mizukoshi; J F Daly
Journal:  Acta Otolaryngol       Date:  1967-07       Impact factor: 1.494

10.  Tobramycin (nebramycin factor 6): in vitro activity against Pseudomonas aeruginosa.

Authors:  R D Meyer; L S Young; D Armstrong
Journal:  Appl Microbiol       Date:  1971-12
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  4 in total

Review 1.  Why monitor serum levels of gentamicin?

Authors:  M Barza; M Lauermann
Journal:  Clin Pharmacokinet       Date:  1978 May-Jun       Impact factor: 6.447

2.  Univariate and multivariate analyses of risk factors predisposing to auditory toxicity in patients receiving aminoglycosides.

Authors:  J M Gatell; F Ferran; V Araujo; M Bonet; E Soriano; J Traserra; J G SanMiguel
Journal:  Antimicrob Agents Chemother       Date:  1987-09       Impact factor: 5.191

3.  The influence of ototoxic drugs on brainstem auditory evoked potentials in man.

Authors:  J M Guerit; P Mahieu; S Houben-Giurgea; S Herbay
Journal:  Arch Otorhinolaryngol       Date:  1981

4.  Shifts in auditory brainstem response latencies following plasma-level-controlled aminoglycoside therapy.

Authors:  M A Hotz; J H Allum; G Kaufmann; F Follath; C R Pfaltz
Journal:  Eur Arch Otorhinolaryngol       Date:  1990       Impact factor: 2.503
  4 in total

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