Literature DB >> 8369967

Morphine-induced potentiation of brain stimulation reward is enhanced by MK-801.

W A Carlezon1, R A Wise.   

Abstract

Morphine (2.5 mg/kg, i.p.) and MK-801 (0.05 mg/kg, i.p.) each enhanced the rewarding impact of electrical stimulation of the medial forebrain bundle, causing small but reliable parallel leftward shifts of the functions relating response rate to stimulation frequency. Administration of MK-801 and morphine together caused a profound leftward shift in the functions. This effect was not due to sensitization to either drug, and suggests that disruption of glutamatergic function can potentiate the rewarding impact of opiates.

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Year:  1993        PMID： 8369967     DOI： 10.1016/0006-8993(93)90177-o

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  14 in total

1.  Morphine and MK-801 administration leads to alternative N-methyl-D-aspartate receptor 1 splicing and associated changes in reward seeking behavior and nociception on an operant orofacial assay.

Authors:  E M Anderson; A Y Del Valle-Pinero; S K Suckow; T A Nolan; J K Neubert; R M Caudle
Journal:  Neuroscience       Date:  2012-04-21       Impact factor: 3.590

2.  Abuse-related effects of µ-opioid analgesics in an assay of intracranial self-stimulation in rats: modulation by chronic morphine exposure.

Authors:  Ahmad A Altarifi; Kenner C Rice; S Stevens Negus
Journal:  Behav Pharmacol       Date:  2013-09       Impact factor: 2.293

3.  Effects of the noncompetitive N-methyl-d-aspartate receptor antagonists ketamine and MK-801 on pain-stimulated and pain-depressed behaviour in rats.

Authors:  T M Hillhouse; S S Negus
Journal:  Eur J Pain       Date:  2016-02-23       Impact factor: 3.931

Review 4.  Intracranial self-stimulation to evaluate abuse potential of drugs.

Authors:  S Stevens Negus; Laurence L Miller
Journal:  Pharmacol Rev       Date:  2014-07       Impact factor: 25.468

5.  Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex.

Authors:  W A Carlezon; R A Wise
Journal:  J Neurosci       Date:  1996-05-01       Impact factor: 6.167

6.  Facilitation of brain stimulation reward by MK-801 (dizocilpine) may be independent of D2-like dopamine receptor stimulation in rats.

Authors:  R L H Clements; A J Greenshaw
Journal:  Psychopharmacology (Berl)       Date:  2005-09-29       Impact factor: 4.530

7.  Some determinants of morphine effects on intracranial self-stimulation in rats: dose, pretreatment time, repeated treatment, and rate dependence.

Authors:  Ahmad A Altarifi; Sidney Stevens Negus
Journal:  Behav Pharmacol       Date:  2011-10       Impact factor: 2.293

8.  NMDA or AMPA/kainate receptor blockade prevents acquisition of conditioned place preference induced by D(2/3) dopamine receptor stimulation in rats.

Authors:  Anna-Maria Biondo; Robert L H Clements; David J Hayes; Brendan Eshpeter; Andrew J Greenshaw
Journal:  Psychopharmacology (Berl)       Date:  2005-03-03       Impact factor: 4.530

9.  Dissociable effects of the noncompetitive NMDA receptor antagonists ketamine and MK-801 on intracranial self-stimulation in rats.

Authors:  Todd M Hillhouse; Joseph H Porter; S Stevens Negus
Journal:  Psychopharmacology (Berl)       Date:  2014-02-13       Impact factor: 4.530

10.  Role of µ-opioid receptor reserve and µ-agonist efficacy as determinants of the effects of µ-agonists on intracranial self-stimulation in rats.

Authors:  Ahmad A Altarifi; Laurence L Miller; S Stevens Negus
Journal:  Behav Pharmacol       Date:  2012-10       Impact factor: 2.293
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