OBJECTIVE: To assess whether asymptomatic abnormalities, including thyroid auto-antibodies, were associated with an abnormal miscarriage rate or a poor obstetric outcome. DESIGN: Prospective study of thyroid auto-antibodies and thyroid function in an unselected obstetric population. SETTING: Saint-Pierrie Hospital, Brussels, Belgium. SUBJECTS: Seven hundred and thirty consecutive pregnant women attending the antenatal clinic. MAIN OUTCOME MEASURES: Miscarriage and pregnancy induced hypertension. RESULTS: Elevated antithyroperoxidase (TPO-Ab) and antithyroglobulin (TG-Ab) antibody titres are associated with an increased miscarriage rate. Also, asymptomatic thyroid abnormalities, mainly abnormal echo-structure but not antithyroid antibodies, are associated with pregnancy induced hypertension. CONCLUSION: The presence of thyroid auto-antibodies during pregnancy constitutes a marker of increased risk of miscarriage and poor obstetric prognosis.
OBJECTIVE: To assess whether asymptomatic abnormalities, including thyroid auto-antibodies, were associated with an abnormal miscarriage rate or a poor obstetric outcome. DESIGN: Prospective study of thyroid auto-antibodies and thyroid function in an unselected obstetric population. SETTING: Saint-Pierrie Hospital, Brussels, Belgium. SUBJECTS: Seven hundred and thirty consecutive pregnant women attending the antenatal clinic. MAIN OUTCOME MEASURES: Miscarriage and pregnancy induced hypertension. RESULTS: Elevated antithyroperoxidase (TPO-Ab) and antithyroglobulin (TG-Ab) antibody titres are associated with an increased miscarriage rate. Also, asymptomatic thyroid abnormalities, mainly abnormal echo-structure but not antithyroid antibodies, are associated with pregnancy induced hypertension. CONCLUSION: The presence of thyroid auto-antibodies during pregnancy constitutes a marker of increased risk of miscarriage and poor obstetric prognosis.
Authors: Mercy Y Laurino; Robin L Bennett; Devki S Saraiya; Lisa Baumeister; Debra Lochner Doyle; Kathleen Leppig; Barbara Pettersen; Robert Resta; Larry Shields; Stefanie Uhrich; Elizabeth A Varga; Wendy H Raskind Journal: J Genet Couns Date: 2005-06 Impact factor: 2.537
Authors: Oluwatosin O Kayode; Ifedayo A Odeniyi; Sandra Iwuala; Oluwarotimi B Olopade; Olufemi A Fasanmade; Augustine E Ohwovoriole Journal: Indian J Endocrinol Metab Date: 2015 Sep-Oct
Authors: Birgit Jatzko; Elisabeth Vytiska-Bistorfer; Alexandra Pawlik; Regina Promberger; Klaus Mayerhofer; Johannes Ott Journal: Reprod Biol Endocrinol Date: 2014-04-05 Impact factor: 5.211