Literature DB >> 8369121

Effects of cocaine on human nasal mucosa.

S H Wang1, H W Wang, J Y Wang.   

Abstract

The effects of cocaine on the contractile response of isolated human nasal mucosal blood vessels to field stimulation and methoxamine were investigated. Results showed that cocaine antagonized methoxamine and inhibited field stimulation. The drug increased resting tension in human nasal mucosa in vitro through direct actions and potentiated mucosal contractions by norepinephrine and epinephrine. The study indicated that high concentrations of cocaine may actually antagonize alpha-adrenoceptors, but these concentrations are not necessary in eliciting desired degrees of vasoconstriction in nasal blood vessels while being applied as a local anesthetic.

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Year:  1993        PMID： 8369121     DOI： 10.1007/bf00171534

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  12 in total

1.  Effect of drugs on the uptake and metabolism of H3-norepinephrine.

Authors:  G HERTING; J AXELROD; L G WHITBY
Journal:  J Pharmacol Exp Ther       Date:  1961-11       Impact factor: 4.030

Review 2.  Pharmacology and therapeutic applications of cocaine.

Authors:  J A Fleming; R Byck; P G Barash
Journal:  Anesthesiology       Date:  1990-09       Impact factor: 7.892

Review 3.  The pharmacology of cocaine related to its abuse.

Authors:  C E Johanson; M W Fischman
Journal:  Pharmacol Rev       Date:  1989-03       Impact factor: 25.468

4.  Do cholinergic neurons directly innervate nasal blood vessels?

Authors:  H W Wang; R T Jackson
Journal:  Rhinology       Date:  1988-06       Impact factor: 3.681

5.  An alternative to the transpalatal maxillary nerve block.

Authors:  W E Taylor; M G Donovan
Journal:  Laryngoscope       Date:  1989-01       Impact factor: 3.325

6.  Myocardial infarction with topical cocaine anesthesia for nasal surgery.

Authors:  Y C Chiu; K Brecht; D S DasGupta; E Mhoon
Journal:  Arch Otolaryngol Head Neck Surg       Date:  1986-09

7.  Interaction of cocaine with nasal mucosa.

Authors:  R T Jackson; S J Hersey
Journal:  Arch Otolaryngol Head Neck Surg       Date:  1991-09

8.  Ventricular fibrillation following local application of cocaine and epinephrine for nasal surgery.

Authors:  P Lormans; D Gaumann; I Schwieger; E Tassonyi
Journal:  ORL J Otorhinolaryngol Relat Spec       Date:  1992       Impact factor: 1.538

9.  Effects of lidocaine and procaine on canine nasal blood vessels.

Authors:  H W Wang; R T Jackson
Journal:  Ann Otol Rhinol Laryngol       Date:  1988 Jul-Aug       Impact factor: 1.547

10.  Mechanism of cocaine potentiation of responses to amines.

Authors:  S Kalsner; M Nickerson
Journal:  Br J Pharmacol       Date:  1969-03       Impact factor: 8.739
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  2 in total

1.  International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.

Authors:  Sarah K Wise; Sandra Y Lin; Elina Toskala; Richard R Orlandi; Cezmi A Akdis; Jeremiah A Alt; Antoine Azar; Fuad M Baroody; Claus Bachert; G Walter Canonica; Thomas Chacko; Cemal Cingi; Giorgio Ciprandi; Jacquelynne Corey; Linda S Cox; Peter Socrates Creticos; Adnan Custovic; Cecelia Damask; Adam DeConde; John M DelGaudio; Charles S Ebert; Jean Anderson Eloy; Carrie E Flanagan; Wytske J Fokkens; Christine Franzese; Jan Gosepath; Ashleigh Halderman; Robert G Hamilton; Hans Jürgen Hoffman; Jens M Hohlfeld; Steven M Houser; Peter H Hwang; Cristoforo Incorvaia; Deborah Jarvis; Ayesha N Khalid; Maritta Kilpeläinen; Todd T Kingdom; Helene Krouse; Desiree Larenas-Linnemann; Adrienne M Laury; Stella E Lee; Joshua M Levy; Amber U Luong; Bradley F Marple; Edward D McCoul; K Christopher McMains; Erik Melén; James W Mims; Gianna Moscato; Joaquim Mullol; Harold S Nelson; Monica Patadia; Ruby Pawankar; Oliver Pfaar; Michael P Platt; William Reisacher; Carmen Rondón; Luke Rudmik; Matthew Ryan; Joaquin Sastre; Rodney J Schlosser; Russell A Settipane; Hemant P Sharma; Aziz Sheikh; Timothy L Smith; Pongsakorn Tantilipikorn; Jody R Tversky; Maria C Veling; De Yun Wang; Marit Westman; Magnus Wickman; Mark Zacharek
Journal:  Int Forum Allergy Rhinol       Date:  2018-02       Impact factor: 3.858

2.  Effects of amphetamine on human nasal mucosa.

Authors:  H W Wang; S H Wang; J Y Wang; W Y Su
Journal:  Eur Arch Otorhinolaryngol       Date:  1996       Impact factor: 2.503
  2 in total

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