Literature DB >> 836843

The effect of S-adenosylhomocysteine on DNA methylation in isolated rat liver nuclei.

R Cox, C Prescott, C C Irving.   

Abstract

DNA methylation was studied in vitro using whole nuclei from regenerating rat liver. Methyl incorporation from S-adenosyl-[Me-3H]methionine in nuclei from regenerating liver was four times higher than that of normal liver. The effect of S-adenosylhomocysteine on DNA methylation was examined, and it was found at equal molar concentrations of S-adenosylhomocysteine to to S-adenosylmethionine that DNA methylation was competitively inhibited 50%.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 836843     DOI： 10.1016/0005-2787(77)90070-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

1.  Down-regulation of S-adenosylhomocysteine hydrolase in the active methyl transfer system in the brain of genetically epileptic El mice.

Authors:  O Ohmori; H Hirano; T Ono; K Abe; T Mita
Journal:  Neurochem Res       Date:  1996-10       Impact factor: 3.996

2.  Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet.

Authors:  M J Wilson; N Shivapurkar; L A Poirier
Journal:  Biochem J       Date:  1984-03-15       Impact factor: 3.857

3.  The characteristics of DNA methylation in an in vitro DNA synthesizing system from mouse fibroblasts.

Authors:  R H Grafstrom; R Yuan; D L Hamilton
Journal:  Nucleic Acids Res       Date:  1985-04-25       Impact factor: 16.971

4.  Methylation of replicating and post-replicated mouse L-cell DNA.

Authors:  Y Gruenbaum; M Szyf; H Cedar; A Razin
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

5.  Regulation of homocysteine metabolism and methylation in human and mouse tissues.

Authors:  Natalie C Chen; Fan Yang; Louis M Capecci; Ziyu Gu; Andrew I Schafer; William Durante; Xiao-Feng Yang; Hong Wang
Journal:  FASEB J       Date:  2010-03-19       Impact factor: 5.191

6.  Escherichia coli S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of action.

Authors:  F Della Ragione; M Porcelli; M Cartenì-Farina; V Zappia; A E Pegg
Journal:  Biochem J       Date:  1985-12-01       Impact factor: 3.857

7.  Influence of prenatal lead exposure on genomic methylation of cord blood DNA.

Authors:  J Richard Pilsner; Howard Hu; Adrienne Ettinger; Brisa N Sánchez; Robert O Wright; David Cantonwine; Alicia Lazarus; Héctor Lamadrid-Figueroa; Adriana Mercado-García; Martha Maria Téllez-Rojo; Mauricio Hernández-Avila
Journal:  Environ Health Perspect       Date:  2009-03-25       Impact factor: 9.031

8.  Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions.

Authors:  J Richard Pilsner; Xinhua Liu; Habibul Ahsan; Vesna Ilievski; Vesna Slavkovich; Diane Levy; Pam Factor-Litvak; Joseph H Graziano; Mary V Gamble
Journal:  Environ Health Perspect       Date:  2008-09-26       Impact factor: 9.031
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.