Literature DB >> 8367284

A quantitative assay to measure the relative DNA-binding affinity of pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) antitumour antibiotics based on the inhibition of restriction endonuclease BamHI.

M S Puvvada1, J A Hartley, T C Jenkins, D E Thurston.   

Abstract

An assay has been developed (restriction endonuclease digestion assay--RED100) based on inhibition of the restriction endonuclease BamHI that is capable of quantitative evaluation of the relative DNA-binding affinity of pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) antitumour antibiotics. This method provides comparable results to those obtained from thermal denaturation and ethidium bromide displacement assays but is much more sensitive, discriminating between molecules of similar structure such as DC-81, iso-DC-81 and neothramycin. The results reveal a trend between relative DNA-binding affinity and in vitro cytotoxicity for the PBDs in two tumour cell lines studied.

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Year:  1993        PMID： 8367284      PMCID： PMC309864          DOI： 10.1093/nar/21.16.3671

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  9 in total

1.  Cleavage by restriction enzymes of DNA modified with the antitumour drug cis-diamminedichloroplatinum(II).

Authors:  Z Balcarová; J Mrázek; V Kleinwächter; V Brabec
Journal:  Gen Physiol Biophys       Date:  1992-12       Impact factor: 1.512

2.  Evaluation of the electrophilicity of DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines by HPLC.

Authors:  S J Morris; D E Thurston; T G Nevell
Journal:  J Antibiot (Tokyo)       Date:  1990-10       Impact factor: 2.649

3.  EcoRV restriction endonuclease binds all DNA sequences with equal affinity.

Authors:  J D Taylor; I G Badcoe; A R Clarke; S E Halford
Journal:  Biochemistry       Date:  1991-09-10       Impact factor: 3.162

4.  The non-covalent interaction of pyrrolo[2, 1-c] [1, 4]benzodiazepine-5, 11-diones with DNA.

Authors:  G B Jones; C L Davey; T C Jenkins; A Kamal; G G Kneale; S Neidle; G D Webster; D E Thurston
Journal:  Anticancer Drug Des       Date:  1990-08

5.  Sequence specific inhibition of DNA restriction enzyme cleavage by PNA.

Authors:  P E Nielsen; M Egholm; R H Berg; O Buchardt
Journal:  Nucleic Acids Res       Date:  1993-01-25       Impact factor: 16.971

Review 6.  Review: ethidium fluorescence assays. Part 1. Physicochemical studies.

Authors:  A R Morgan; J S Lee; D E Pulleyblank; N L Murray; D H Evans
Journal:  Nucleic Acids Res       Date:  1979-10-10       Impact factor: 16.971

7.  DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs.

Authors:  R P Hertzberg; S M Hecht; V L Reynolds; I J Molineux; L H Hurley
Journal:  Biochemistry       Date:  1986-03-25       Impact factor: 3.162

8.  EcoRV restriction endonuclease: communication between catalytic metal ions and DNA recognition.

Authors:  C L Vermote; S E Halford
Journal:  Biochemistry       Date:  1992-07-07       Impact factor: 3.162

9.  Anthramycin inhibition of restriction endonuclease cleavage and its use as a reversible blocking agent in DNA constructions.

Authors:  W Sumner; G N Bennett
Journal:  Nucleic Acids Res       Date:  1981-05-11       Impact factor: 16.971
  9 in total
  9 in total

1.  Identification of the dioxygenase-generated intermediate formed during biosynthesis of the dihydropyrrole moiety common to anthramycin and sibiromycin.

Authors:  Shalini Saha; Wei Li; Barbara Gerratana; Steven E Rokita
Journal:  Bioorg Med Chem       Date:  2014-12-20       Impact factor: 3.641

2.  Binding and interaction of di- and tri-substituted organometallic triptycene palladium complexes with DNA.

Authors:  Rina Kumari; Sourav Bhowmick; Neeladri Das; Prolay Das
Journal:  J Biol Inorg Chem       Date:  2014-07-27       Impact factor: 3.358

Review 3.  Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines.

Authors:  Barbara Gerratana
Journal:  Med Res Rev       Date:  2010-06-13       Impact factor: 12.944

4.  DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents.

Authors:  Khondaker M Rahman; Higia Vassoler; Colin H James; David E Thurston
Journal:  ACS Med Chem Lett       Date:  2010-08-13       Impact factor: 4.345

5.  Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca.

Authors:  Evan M Alexander; Dale F Kreitler; Valeria Guidolin; Alexander K Hurben; Eric Drake; Peter W Villalta; Silvia Balbo; Andrew M Gulick; Courtney C Aldrich
Journal:  ACS Infect Dis       Date:  2020-06-24       Impact factor: 5.084

6.  A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors.

Authors:  Yelena Y Janjigian; Wooin Lee; Mark G Kris; Vincent A Miller; Lee M Krug; Christopher G Azzoli; Emir Senturk; M Wade Calcutt; Naiyer A Rizvi
Journal:  Cancer Chemother Pharmacol       Date:  2009-08-12       Impact factor: 3.333

7.  Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexes.

Authors:  Khondaker M Rahman; David B Corcoran; Tam T T Bui; Paul J M Jackson; David E Thurston
Journal:  PLoS One       Date:  2014-08-18       Impact factor: 3.240

8.  Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments.

Authors:  Julia Mantaj; Paul J M Jackson; Kersti Karu; Khondaker M Rahman; David E Thurston
Journal:  PLoS One       Date:  2016-04-07       Impact factor: 3.240

Review 9.  From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).

Authors:  Julia Mantaj; Paul J M Jackson; Khondaker M Rahman; David E Thurston
Journal:  Angew Chem Int Ed Engl       Date:  2016-11-15       Impact factor: 15.336
  9 in total

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