Literature DB >> 8366089

Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells.

T Bessho1, K Tano, H Kasai, E Ohtsuka, S Nishimura.   

Abstract

Two DNA repair enzymes for 8-hydroxyguanine (also known as 7,8-dihydro-8-oxoguanine; OH8Gua, oxo8Gua) have been identified in human HeLa cell nuclear extract. One is OH8Gua-glycosylase and the other is OH8Gua-endonuclease that lacks OH8Gua-glycosylase activity. They were separated by heparin-Sepharose column chromatography and characterized by endonuclease nicking assay or by measuring the OH8Gua released from substrate DNA using high pressure liquid chromatography-electrochemical detection. Both OH8Gua repair enzymes act only on the OH8Gua-containing strand of the duplex substrate DNA containing OH8Gua/C, OH8Gua/T, or OH8Gua/G. DNA containing OH8Gua/A base pair was very poor substrate for either enzymes. OH8Gua-endonuclease simultaneously cleaves phosphodiester bonds on both sides of the OH8Gua residue, leaving 5'-hydroxy and 3'-hydroxy groups.

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Year:  1993        PMID： 8366089

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  36 in total

Review 1.  DNA glycosylases in the base excision repair of DNA.

Authors:  H E Krokan; R Standal; G Slupphaug
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

2.  Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.

Authors:  J P Radicella; C Dherin; C Desmaze; M S Fox; S Boiteux
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

3.  In vitro repair of oxidative DNA damage by human nucleotide excision repair system: possible explanation for neurodegeneration in xeroderma pigmentosum patients.

Authors:  J T Reardon; T Bessho; H C Kung; P H Bolton; A Sancar
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

4.  Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.

Authors:  M Bjorâs; L Luna; B Johnsen; E Hoff; T Haug; T Rognes; E Seeberg
Journal:  EMBO J       Date:  1997-10-15       Impact factor: 11.598

Review 5.  Oxidative DNA damage repair in mammalian cells: a new perspective.

Authors:  Tapas K Hazra; Aditi Das; Soumita Das; Sujata Choudhury; Yoke W Kow; Rabindra Roy
Journal:  DNA Repair (Amst)       Date:  2006-11-20

6.  Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.

Authors:  T A Rosenquist; D O Zharkov; A P Grollman
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

7.  Site-directed photoproteolysis of 8-oxoguanine DNA glycosylase 1 (OGG1) by specific porphyrin-protein probe conjugates: a strategy to improve the effectiveness of photodynamic therapy for cancer.

Authors:  Kimberly A Conlon; Miguel Berrios
Journal:  J Photochem Photobiol B       Date:  2006-12-15       Impact factor: 6.252

8.  Expression of the E. coli fpg gene in mammalian cells reduces the mutagenicity of gamma-rays.

Authors:  F Laval
Journal:  Nucleic Acids Res       Date:  1994-11-25       Impact factor: 16.971

9.  Leukocyte 8-hydroxydeoxyguanosine and aromatic DNA adduct in coke-oven workers with polycyclic aromatic hydrocarbon exposure.

Authors:  J Zhang; M Ichiba; T Hanaoka; G Pan; Y Yamano; K Hara; K Takahashi; K Tomokuni
Journal:  Int Arch Occup Environ Health       Date:  2003-07-03       Impact factor: 3.015

10.  Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine.

Authors:  P A van der Kemp; D Thomas; R Barbey; R de Oliveira; S Boiteux
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205
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