Literature DB >> 8365722

Physical mapping of chromosome 3p25-p26 by fluorescence in situ hybridisation (FISH).

M E Phipps1, E R Maher, N A Affara, F Latif, M A Leversha, M E Ferguson-Smith, Y Nakamura, M Lerman, B Zbar, M A Ferguson-Smith.   

Abstract

As part of our effort to isolate and characterise the von Hippel-Lindau (VHL) disease gene, we constructed a physical map of chromosome 3p25-26 by fluorescence in situ hybridisation (FISH) studies on a panel of cytogenetic rearrangements involving this region. Biotinylated cosmid and lambda probes were hybridised to metaphase chromosome spreads and positioned with respect to each cytogenetic breakpoint. These studies unequivocally established the order of five loci linked to the VHL disease gene: cen-(RAF1,312)-D3S732-D3S1250-D3S601-D3S18 -pter and determined the position of three other probes within this map. These results ordered RAF1 and D3S732 for the first time, confirmed the localisation of D3S1250 between RAF1 and D3S601 and determined the position of D3S651 with respect to other chromosome 3p25-p26 loci. The establishment of an ordered set of cytogenetic aberrations will enable the rapid assignment of polymorphic and nonpolymorphic cloned sequences within the chromosome region 3p25-p26.

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Year:  1993        PMID： 8365722     DOI： 10.1007/bf00216139

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  19 in total

1.  Three distinct regions involved in 3p deletion in human lung cancer.

Authors:  K Hibi; T Takahashi; K Yamakawa; R Ueda; Y Sekido; Y Ariyoshi; M Suyama; H Takagi; Y Nakamura; T Takahashi
Journal:  Oncogene       Date:  1992-03       Impact factor: 9.867

2.  Mother and son with deletion of 3p25-pter.

Authors:  J Tazelaar; J Roberson; D L Van Dyke; V R Babu; L Weiss
Journal:  Am J Med Genet       Date:  1991-05-01

3.  Partial deletion of the short arm of chromosome 3: further delineation of the 3p25-3pter syndrome.

Authors:  R M Reifen; R Gale; E Kerem; Y Armon; A Brand; J Dagan; G Kohn
Journal:  Clin Genet       Date:  1986-08       Impact factor: 4.438

4.  Partial deletion of the short arm of chromosome 3.

Authors:  J L Tolmie; P Batstone; I Ruthven; D H Gilmore
Journal:  Clin Genet       Date:  1986-06       Impact factor: 4.438

5.  Specific genetic change in tumors associated with von Hippel-Lindau disease.

Authors:  K Tory; H Brauch; M Linehan; D Barba; E Oldfield; M Filling-Katz; B Seizinger; Y Nakamura; R White; F F Marshall
Journal:  J Natl Cancer Inst       Date:  1989-07-19       Impact factor: 13.506

6.  Clinical features and natural history of von Hippel-Lindau disease.

Authors:  E R Maher; J R Yates; R Harries; C Benjamin; R Harris; A T Moore; M A Ferguson-Smith
Journal:  Q J Med       Date:  1990-11

7.  Genetic linkage between von Hippel-Lindau disease and three microsatellite polymorphisms refines the localisation of the VHL locus.

Authors:  P A Crossey; E R Maher; M H Jones; F M Richards; F Latif; M E Phipps; M Lush; K Foster; K Tory; J S Green
Journal:  Hum Mol Genet       Date:  1993-03       Impact factor: 6.150

8.  Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma.

Authors:  E R Maher; J R Yates; M A Ferguson-Smith
Journal:  J Med Genet       Date:  1990-05       Impact factor: 6.318

9.  Von Hippel-Lindau disease: a genetic study.

Authors:  E R Maher; L Iselius; J R Yates; M Littler; C Benjamin; R Harris; J Sampson; A Williams; M A Ferguson-Smith; N Morton
Journal:  J Med Genet       Date:  1991-07       Impact factor: 6.318

10.  Detailed genetic mapping of the von Hippel-Lindau disease tumour suppressor gene.

Authors:  F M Richards; E R Maher; F Latif; M E Phipps; K Tory; M Lush; P A Crossey; B Oostra; P Enblad; K H Gustavson
Journal:  J Med Genet       Date:  1993-02       Impact factor: 6.318
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  2 in total

1.  Surgical decision-making affected by clinical and genetic screening of a novel kindred with von Hippel-Lindau disease and pancreatic islet cell tumors.

Authors:  S A Curley; S T Lott; J W Luca; M L Frazier; A M Killary
Journal:  Ann Surg       Date:  1998-02       Impact factor: 12.969

2.  Clinical and mutation analysis of four Chinese families with von Hippel-Lindau disease.

Authors:  J Chen; W Geng; Y Zhao; H Zhao; G Wang; F Huang; F Liu; X Geng
Journal:  Clin Transl Oncol       Date:  2012-11-10       Impact factor: 3.405
  2 in total

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