Literature DB >> 8365494

A complex of rab3A, SNAP-25, VAMP/synaptobrevin-2 and syntaxins in brain presynaptic terminals.

H P Horikawa1, H Saisu, T Ishizuka, Y Sekine, A Tsugita, S Odani, T Abe.   

Abstract

Two monoclonal antibodies (SPM-1 and SPM-2) immunoprecipitate brain N-type calcium channels. On immunoaffinity chromatography of digitonin extracts of bovine brain membranes on SPM-1- and SPM-2-Sepharose, proteins of 36 (syntaxins A and B), 28 and 19 kDa are specifically retained by both columns. Here we show that the 19 and 28 kDa bands contain VAMP/synaptobrevin-2, and rab3A/smg25A and SNAP-25, respectively. Since SPM-1 and SPM-2 recognize only syntaxins and the 28 kDa band (rab3A/sm25A and SNAP-25), respectively, the results indicate that all these proteins form a complex. Our results suggest tight linkage between the components involved in neurotransmitter release.

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Year:  1993        PMID： 8365494     DOI： 10.1016/0014-5793(93)80281-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

Review 1.  Protein-protein interactions and protein modules in the control of neurotransmitter release.

Authors:  F Benfenati; F Onofri; S Giovedí
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-02-28       Impact factor: 6.237

Review 2.  Acetylcholine release and the cholinergic genomic locus.

Authors:  M Israël; Y Dunant
Journal:  Mol Neurobiol       Date:  1998-02       Impact factor: 5.590

3.  The soluble N-ethylmaleimide-sensitive factor attached protein receptor complex in growth cones: molecular aspects of the axon terminal development.

Authors:  M Igarashi; M Tagaya; Y Komiya
Journal:  J Neurosci       Date:  1997-02-15       Impact factor: 6.167

4.  Mouse model of hyperkinesis implicates SNAP-25 in behavioral regulation.

Authors:  E J Hess; K A Collins; M C Wilson
Journal:  J Neurosci       Date:  1996-05-01       Impact factor: 6.167

Review 5.  Regulated vesicular fusion in neurons: snapping together the details.

Authors:  I C Bark; M C Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

6.  Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neural development.

Authors:  I C Bark; K M Hahn; A E Ryabinin; M C Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

7.  SNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis.

Authors:  P P Mehta; E Battenberg; M C Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

8.  Binding and labeling of omega-conotoxin GVIA in crude membranes from subfractionated fractions and various areas of chick brain.

Authors:  S Ichida; T Wada; K Hashimoto; Y Kasamatsu; T Akimoto; M Tahara
Journal:  Neurochem Res       Date:  1996-06       Impact factor: 3.996

9.  Expression of vesicle-associated membrane protein 2 (VAMP-2)/synaptobrevin II and cellubrevin in rat skeletal muscle and in a muscle cell line.

Authors:  A Volchuk; Y Mitsumoto; L He; Z Liu; E Habermann; W Trimble; A Klip
Journal:  Biochem J       Date:  1994-11-15       Impact factor: 3.857

10.  Regulation of quantal shape by Rab3A: evidence for a fusion pore-dependent mechanism.

Authors:  Xueyong Wang; Ramachandran Thiagarajan; Qingbo Wang; Teclemichael Tewolde; Mark M Rich; Kathrin L Engisch
Journal:  J Physiol       Date:  2008-06-26       Impact factor: 5.182
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