BACKGROUND: Recent studies have indicated that infection with Helicobacter pylori is closely associated with increased risk for gastric cancer. Previous studies, however, usually have been made on cases of advanced gastric cancer. METHODS: The Congo red-methylene blue test was performed on 19 healthy subjects, 24 patients with early gastric cancer of differentiated type, and 17 patients with early cancer of undifferentiated type. H. pylori infection was examined by culture of biopsy specimens obtained from noncancerous antral mucosa. RESULTS: H. pylori was detected in 19 (79%) of 24 patients with differentiated-type early gastric cancer, but in only 5 (29%) of 17 patients with undifferentiated-type early gastric cancer; this difference was statistically significant. It also was detected significantly more frequently in patients with differentiated cancers than in healthy subjects. CONCLUSIONS: H. pylori infection was closely associated with differentiated-type gastric cancers, but not with undifferentiated types.
BACKGROUND: Recent studies have indicated that infection with Helicobacter pylori is closely associated with increased risk for gastric cancer. Previous studies, however, usually have been made on cases of advanced gastric cancer. METHODS: The Congo red-methylene blue test was performed on 19 healthy subjects, 24 patients with early gastric cancer of differentiated type, and 17 patients with early cancer of undifferentiated type. H. pyloriinfection was examined by culture of biopsy specimens obtained from noncancerous antral mucosa. RESULTS:H. pylori was detected in 19 (79%) of 24 patients with differentiated-type early gastric cancer, but in only 5 (29%) of 17 patients with undifferentiated-type early gastric cancer; this difference was statistically significant. It also was detected significantly more frequently in patients with differentiated cancers than in healthy subjects. CONCLUSIONS:H. pyloriinfection was closely associated with differentiated-type gastric cancers, but not with undifferentiated types.
Authors: H Tabata; T Fuchigami; H Kobayashi; Y Sakai; M Nakanishi; K Tomioka; S Nakamura; M Fujishima Journal: Dig Dis Sci Date: 1999-10 Impact factor: 3.199
Authors: Soo-Jeong Cho; Il Ju Choi; Chan Gyoo Kim; Jong Yeul Lee; Myeong-Cherl Kook; Moon-Woo Seong; Sook Ryun Park; Jong Seok Lee; Young-Woo Kim; Keun Won Ryu; Jun Ho Lee; Byung-Ho Nam; Young-Iee Park Journal: Gut Liver Date: 2010-12-17 Impact factor: 4.519
Authors: T Kunori; F Shinya; T Satomi; J Itoh; M Abe; M Takahashi; T Yokota; Y Abe; K Hiraoka; S Kawaguchi; I Tanaka; M Mochizuki; S Asano Journal: J Gastroenterol Date: 1996-04 Impact factor: 7.527