Literature DB >> 836432

Lack of correlation between structural features and function of synthetic agents tested for leukocyte chemotaxis.

T W Jungi.   

Abstract

A number of proteins, poly-L-amino acids, oligopeptides and lipids were tested for neutrophil, eosinophil and macrophage chemotactic activity. One myoglobin preparation was active. Based on the negative findings for all other substances, primary structure, secondary structure, degree of hydrophobicity, size and charge of a molecule, could be ruled out as structural features recognized by chemotactically responding phagocytes.

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Year:  1977        PMID： 836432     DOI： 10.1007/BF01936774

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  [Isolation of a basic polypeptide with leukotactic and permeation-accelerating effect].

Authors:  M FRIMMER; D HEGNER
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1963

2.  Assay of chemotaxis by a reversible Boyden chamber eliminating cell detachment.

Authors:  T W Jungi
Journal:  Int Arch Allergy Appl Immunol       Date:  1975

3.  The chemotactic properties of the products of collagenolysis.

Authors:  J Houck; C Chang
Journal:  Proc Soc Exp Biol Med       Date:  1971-10

4.  [Isolation of a 2nd polypeptide with leukotactic and permeation-promoting effects from calf thymus].

Authors:  M Frimmer; B Zeidler
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1965-08-20

5.  Characterization of the chemotactic activity of casein for neutrophil leucocytes and macrophages.

Authors:  P C Wilkinson
Journal:  Experientia       Date:  1972-09-15

6.  A fragment of the third component of human complement with anaphylatoxin activity.

Authors:  D B Budzko; V A Bokisch; H J Müller-Eberhard
Journal:  Biochemistry       Date:  1971-03-30       Impact factor: 3.162

7.  Recognition of protein structure in leukocyte chemotaxis.

Authors:  P C Wilkinson
Journal:  Nature       Date:  1973-08-24       Impact factor: 49.962

8.  The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils.

Authors:  H J Showell; R J Freer; S H Zigmond; E Schiffmann; S Aswanikumar; B Corcoran; E L Becker
Journal:  J Exp Med       Date:  1976-05-01       Impact factor: 14.307

9.  Formation of C3a and C5a anaphylatoxins in whole human serum after inhibition of the anaphylatoxin inactivator.

Authors:  E H Vallota; H J Müller-Eberhard
Journal:  J Exp Med       Date:  1973-05-01       Impact factor: 14.307

10.  A prealbumin activator of prekallikrein. 3. Appearance of chemotactic activity for human neutrophils by the conversion of human prekallikrein to kallikrein.

Authors:  A P Kaplan; A B Kay; K F Austen
Journal:  J Exp Med       Date:  1972-01       Impact factor: 14.307
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