Literature DB >> 836425

The local anesthetic potency of norcocaine, a metabolite of cocaine.

W W Just, J Hoyer.   

Abstract

The local anesthetic effects of cocaine and one of its main metabolites norcocaine, were investigated comparatively on isolated ganglion cells of the marine gastropod, Aplysia californica. During a 4-hour-period, different action potential parameters such as amplitude, duration, maximum rate of rise were observed, which demonstrated that norcocaine exhibits a higher local anesthetic potency than cocaine.

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Year:  1977        PMID： 836425     DOI： 10.1007/BF01936761

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  Effect of procaine on electrical properties of squid axon membrane.

Authors:  R E TAYLOR
Journal:  Am J Physiol       Date:  1959-05

2.  Local anesthetics. I. The blocking potencies of some local anesthetics and of butyl alcohol determined on peripheral nerves.

Authors:  J C SKOU
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1954

3.  A study on the mechanism of action of cocaine on amphibian peripheral nerve.

Authors:  G A CONDOURIS
Journal:  J Pharmacol Exp Ther       Date:  1961-02       Impact factor: 4.030

4.  Site of action and active form of local anesthetics.

Authors:  T Narahashi; D T Frazier
Journal:  Neurosci Res (N Y)       Date:  1971

5.  Norcocaine: a pharmacologically active metabolite of cocaine found in brain.

Authors:  R L Hawks; I J Kopin; R W Colburn; N B Thoa
Journal:  Life Sci       Date:  1974-12-15       Impact factor: 5.037
  5 in total
  4 in total

1.  Dose-response cocaine pharmacokinetics and metabolite profile following intravenous administration and arterial sampling in unanesthetized, freely moving male rats.

Authors:  R M Booze; A F Lehner; D R Wallace; M A Welch; C F Mactutus
Journal:  Neurotoxicol Teratol       Date:  1997 Jan-Feb       Impact factor: 3.763

2.  Sex differences in plasma cocaine levels and subjective effects after acute cocaine administration in human volunteers.

Authors:  S E Lukas; M Sholar; L H Lundahl; X Lamas; E Kouri; J D Wines; L Kragie; J H Mendelson
Journal:  Psychopharmacology (Berl)       Date:  1996-06       Impact factor: 4.530

3.  Cocaine Causes Apoptotic Death in Rat Mesencephalon and Striatum Primary Cultures.

Authors:  Lucilia B Lepsch; Cleopatra S Planeta; Critoforo Scavone
Journal:  Biomed Res Int       Date:  2015-07-29       Impact factor: 3.411

Review 4.  Sense and Insensibility - An Appraisal of the Effects of Clinical Anesthetics on Gastropod and Cephalopod Molluscs as a Step to Improved Welfare of Cephalopods.

Authors:  William Winlow; Gianluca Polese; Hadi-Fathi Moghadam; Ibrahim A Ahmed; Anna Di Cosmo
Journal:  Front Physiol       Date:  2018-08-24       Impact factor: 4.566
  4 in total

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