Literature DB >> 8363723

Can soluble antigens induce CD8+ cytotoxic T-cell responses? A paradox revisited.

S Raychaudhuri1, W J Morrow.   

Abstract

Cytotoxic T lymphocyte (CTL) induction usually follows processing of antigens via endogenous pathways before presentation on the cell surface in association with MHC class I molecules. Soluble antigens do not, in general, induce specific CTL responses. Here, Syamal Raychaudhuri and John Morrow suggest that a novel adjuvant formulation can elicit CTL responses to soluble antigens and discuss the implications for vaccine development.

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Year:  1993        PMID： 8363723     DOI： 10.1016/0167-5699(93)90233-B

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  7 in total

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Review 5.  Heat shock proteins transfer peptides during antigen processing and CTL priming.

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  7 in total

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