Literature DB >> 8363722

Antigen presentation, loss of immunological memory and AIDS.

M R Helbert1, J L'age-Stehr, N A Mitchison.   

Abstract

A key factor causing immunodeficiency in HIV infection seems to be defective antigen presentation. Consequently, CD4+ T-cell populations, initially those expressing CD45RO, decrease in number not because of their destruction, but because they fail to expand in response to antigenic stimulation. This view implies that it would be mistaken to aim therapies only at correcting T-cell function or preventing infection of T cells.

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Year:  1993        PMID： 8363722     DOI： 10.1016/0167-5699(93)90232-A

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  12 in total

Review 1.  Monitoring patients with HIV disease.

Authors:  M Helbert; J Breuer
Journal:  J Clin Pathol       Date:  2000-04       Impact factor: 3.411

2.  Modulation of T cell responses to recall antigens presented by Langerhans cells in HIV-discordant identical twins by anti-interleukin (IL)-10 antibodies and IL-12.

Authors:  A Blauvelt; C Chougnet; G M Shearer; S I Katz
Journal:  J Clin Invest       Date:  1996-03-15       Impact factor: 14.808

3.  Interleukin 12 exerts a differential effect on the maturation of neonatal and adult human CD45R0- CD4 T cells.

Authors:  U Shu; C E Demeure; D G Byun; F Podlaski; A S Stern; G Delespesse
Journal:  J Clin Invest       Date:  1994-10       Impact factor: 14.808

4.  Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects.

Authors:  P De Paoli; S Zanussi; C Simonelli; M T Bortolin; M D'Andrea; C Crepaldi; R Talamini; M Comar; M Giacca; U Tirelli
Journal:  J Clin Invest       Date:  1997-12-01       Impact factor: 14.808

5.  An early antigen-presenting cell defect in HIV-1-infected patients correlates with CD4 dependency in human T-cell clones.

Authors:  S J Fidler; L Dorrell; S Ball; G Lombardi; J Weber; C Hawrylowicz; A D Rees
Journal:  Immunology       Date:  1996-09       Impact factor: 7.397

Review 6.  Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy.

Authors:  Gadi Borkow; Zvi Bentwich
Journal:  Clin Microbiol Rev       Date:  2004-10       Impact factor: 26.132

7.  Vitamin D binding protein-macrophage activating factor directly inhibits proliferation, migration, and uPAR expression of prostate cancer cells.

Authors:  Kalvin J Gregory; Bing Zhao; Diane R Bielenberg; Sami Dridi; Jason Wu; Weihua Jiang; Bin Huang; Steven Pirie-Shepherd; Michael Fannon
Journal:  PLoS One       Date:  2010-10-18       Impact factor: 3.240

8.  Expression patterns of Fc gamma receptors, HLA-DR and selected adhesion molecules on monocytes from normal and HIV-infected individuals.

Authors:  C Locher; G Vanham; L Kestens; M Kruger; J L Ceuppens; J Vingerhoets; P Gigase
Journal:  Clin Exp Immunol       Date:  1994-10       Impact factor: 4.330

9.  Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression.

Authors:  P Borrow; C F Evans; M B Oldstone
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103

10.  CD4(+) T Cell Response to Lamivudine, Stavudine and Nevirapine in Human Immunodeficiency Virus Infected Antiretroviral-Naive Men in Nigeria.

Authors:  Waidi Folorunso Sule; Enejoh Simon Sani
Journal:  Indian J Virol       Date:  2011-08-02
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