M Karita1, Q Li, K Okita. 1. First Department of Internal Medicine, Yamaguchi University, School of Medicine, Japan.
Abstract
OBJECTIVES: developing a new therapy for eradication of H. pylori by using the nude mouse model. METHODS: By quantifying the number of colonies of Helicobacter pylori and the score of H. pylori-associated gastritis from the gastric tissue following different drug regimens in inoculated nude mice, we evaluated the effectiveness of each regimen, including a new drug, plaunotol. Drugs were administered daily for a 1-wk period, beginning 4 wk after inoculation. RESULTS: In the examination after therapy, the number of colonies of H. pylori and the score of gastritis in the triple-therapy group were significantly lower than in any of the singly- and dual-drug groups or control group from 5 wk to the end of the study after inoculation. Inflammation of the stomach was less apparent in the treatment groups than in the control group. CONCLUSION: With the nude mouse model, we quantitatively demonstrated that the new triple therapy is the most effective therapy for eradication of H. pylori.
OBJECTIVES: developing a new therapy for eradication of H. pylori by using the nude mouse model. METHODS: By quantifying the number of colonies of Helicobacter pylori and the score of H. pylori-associated gastritis from the gastric tissue following different drug regimens in inoculated nude mice, we evaluated the effectiveness of each regimen, including a new drug, plaunotol. Drugs were administered daily for a 1-wk period, beginning 4 wk after inoculation. RESULTS: In the examination after therapy, the number of colonies of H. pylori and the score of gastritis in the triple-therapy group were significantly lower than in any of the singly- and dual-drug groups or control group from 5 wk to the end of the study after inoculation. Inflammation of the stomach was less apparent in the treatment groups than in the control group. CONCLUSION: With the nude mouse model, we quantitatively demonstrated that the new triple therapy is the most effective therapy for eradication of H. pylori.
Authors: J G Smith; L Kong; G K Abruzzo; C J Gill; A M Flattery; P M Scott; D Bramhill; C Cioffe; C M Thompson; K Bartizal Journal: Clin Diagn Lab Immunol Date: 1996-01
Authors: L Kong; J G Smith; D Bramhill; G K Abruzzo; C Bonfiglio; C Cioffe; A M Flattery; C J Gill; L Lynch; P M Scott; L Silver; C Thompson; H Kropp; K Bartizal Journal: Clin Diagn Lab Immunol Date: 1996-01
Authors: S Matsumoto; Y Washizuka; Y Matsumoto; S Tawara; F Ikeda; Y Yokota; M Karita Journal: Antimicrob Agents Chemother Date: 1997-12 Impact factor: 5.191