Literature DB >> 8361994

P450 enzymes of estrogen metabolism.

C P Martucci1, J Fishman.   

Abstract

Endogenous and exogenous estrogens undergo extensive oxidative metabolism by specific cytochrome P450 enzymes. Certain drugs and xenobiotics have been found to be potent inducers of estrogen hydroxylating enzymes with C-2 hydroxylase induction being greater than that of C-16 hydroxylase. Oxygenated estrogen metabolites have different biological activities, with C-2 metabolites having limited or no activity and C-4 and C-16 metabolites having similar potency to estradiol. Pathophysiological roles for some of the oxygenated estrogen metabolites have been proposed, e.g. 16 alpha-hydroxyestrone and 4-hydroxyestrone. These reactive estrogens are capable of damaging cellular proteins and DNA and may be carcinogenic in specific cells.

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Year:  1993        PMID： 8361994     DOI： 10.1016/0163-7258(93)90057-k

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  68 in total

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Authors:  Michele L Cote; Wonsuk Yoo; Angela S Wenzlaff; Geoffrey M Prysak; Susan K Santer; Gina B Claeys; Alison L Van Dyke; Susan J Land; Ann G Schwartz
Journal:  Carcinogenesis       Date:  2009-01-27       Impact factor: 4.944

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6.  Association of CYP1B1 haplotypes and breast cancer risk in Caucasian women.

Authors:  Yifan Huang; Amy Trentham-Dietz; Montserrat García-Closas; Polly A Newcomb; Linda Titus-Ernstoff; John M Hampton; Stephen J Chanock; Jonathan L Haines; Kathleen M Egan
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7.  Changes in the gene expression pattern induced by 2-methoxyestradiol in the mouse uterus.

Authors:  Ramiro J Rincón-Rodríguez; María L Oróstica; Patricia Díaz; Patricia Reuquén; Hugo Cárdenas; Pedro A Orihuela
Journal:  Endocrine       Date:  2013-03-15       Impact factor: 3.633

8.  Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis.

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Review 9.  Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis.

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10.  The effect of ketoconazole and diltiazem on oestrogen metabolism in postmenopausal women after single dose oestradiol treatment.

Authors:  Anita Annas; Kjell Carlström; Gunnar Alván; Ayman AL-Shurbaji
Journal:  Br J Clin Pharmacol       Date:  2003-09       Impact factor: 4.335
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