Literature DB >> 8361646

CSF and serum metabolic profile of patients with Huntington's chorea: a study by high resolution proton NMR spectroscopy and HPLC.

F Nicoli1, J Vion-Dury, J M Maloteaux, C Delwaide, S Confort-Gouny, M Sciaky, P J Cozzone.   

Abstract

We studied both cerebrospinal fluid (CSF) and serum of 11 patients suffering from Huntington's disease (HD) and 12 control subjects by combining high resolution proton NMR spectroscopy and HPLC. NMR spectroscopy analysis of the CSF shows a significant increase (60%) in pyruvate concentration in HD patients. No unexpected molecules were detected. Glutamate, glutamine, aspartate, proline and GABA levels were found unchanged in the CSF of HD patients, using HPLC analysis. Conversely, a significant increase (30%) in the CSF level of glycine was detected. These observations are in agreement with the metabolic hypothesis of HD physiopathogenesis. In addition, the protocol combining NMR spectroscopy and HPLC provides a straightforward evaluation of brain metabolic status and blood-brain-barrier function.

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Year:  1993        PMID： 8361646     DOI： 10.1016/0304-3940(93)90168-k

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  13 in total

Review 1.  NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance.

Authors:  V Calabrese; T E Bates; A M Stella
Journal:  Neurochem Res       Date:  2000-10       Impact factor: 3.996

2.  Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy.

Authors:  Ivan Tkac; Janet M Dubinsky; C Dirk Keene; Rolf Gruetter; Walter C Low
Journal:  J Neurochem       Date:  2007-01-08       Impact factor: 5.372

Review 3.  Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity.

Authors:  V Calabrese; G Scapagnini; A M Giuffrida Stella; T E Bates; J B Clark
Journal:  Neurochem Res       Date:  2001-06       Impact factor: 3.996

4.  Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease.

Authors:  D S Reynolds; R J Carter; A J Morton
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

5.  Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice.

Authors:  P Matthew Joyner; Ronni M Matheke; Lindsey M Smith; Robert H Cichewicz
Journal:  J Proteome Res       Date:  2010-01       Impact factor: 4.466

Review 6.  What might be the impact on neurology of the analysis of brain metabolism by in vivo magnetic resonance spectroscopy?

Authors:  J Vion-Dury; D J Meyerhoff; P J Cozzone; M W Weiner
Journal:  J Neurol       Date:  1994-05       Impact factor: 4.849

Review 7.  The energetics of Huntington's disease.

Authors:  Susan E Browne; M Flint Beal
Journal:  Neurochem Res       Date:  2004-03       Impact factor: 3.996

8.  Low anaerobic threshold and increased skeletal muscle lactate production in subjects with Huntington's disease.

Authors:  Andrea Ciammola; Jenny Sassone; Monica Sciacco; Niccolò E Mencacci; Michela Ripolone; Caterina Bizzi; Clarissa Colciago; Maurizio Moggio; Gianfranco Parati; Vincenzo Silani; Gabriella Malfatto
Journal:  Mov Disord       Date:  2010-10-07       Impact factor: 10.338

9.  Rapid etiological classification of meningitis by NMR spectroscopy based on metabolite profiles and host response.

Authors:  Uwe Himmelreich; Richard Malik; Till Kühn; Heide-Marie Daniel; Ray L Somorjai; Brion Dolenko; Tania C Sorrell
Journal:  PLoS One       Date:  2009-04-24       Impact factor: 3.240

10.  Localization of glycine receptors in the human forebrain, brainstem, and cervical spinal cord: an immunohistochemical review.

Authors:  Kristin Baer; Henry J Waldvogel; Richard L M Faull; Mark I Rees
Journal:  Front Mol Neurosci       Date:  2009-11-04       Impact factor: 5.639
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